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Database: UniProt
Entry: I7MDP9_TETTS
LinkDB: I7MDP9_TETTS
Original site: I7MDP9_TETTS 
ID   I7MDP9_TETTS            Unreviewed;       718 AA.
AC   I7MDP9;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   07-JUN-2017, entry version 23.
DE   SubName: Full=Cation channel family transporter {ECO:0000313|EMBL:EAR90720.2};
GN   ORFNames=TTHERM_00706350 {ECO:0000313|EMBL:EAR90720.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90720.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662794; EAR90720.2; -; Genomic_DNA.
DR   RefSeq; XP_001010965.2; XM_001010965.2.
DR   GeneID; 7840196; -.
DR   KEGG; tet:TTHERM_00706350; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF232; PTHR10037:SF232; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     82     98       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    187    204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    225    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    398    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    430    452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    464    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    521    545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    580    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    611    635       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    316       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      399    638       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   718 AA;  85851 MW;  F05DD2BDCE06F442 CRC64;
     MFDKGVHFRD NVDSQSRSRT QKSILSSYSI KQNYRESINE TLNSDVSAIA KLSDFKDLLI
     EARTINTTEK GLKSMKTYNK LTLLRQFSFV ILILLAFFER PIWCTNQYND YCRVSPEGVR
     IPTSNIPYIQ IQYYYPIEIL VVCFLTYNRY LNQSFLKVNK QKYWFYTIIT ITLVLITEDI
     VKATYDAYPI NISLFLKPLY FISFNRILRR TIKIYAKIIQ KVLPIFIIIA LNIMFFALLG
     RIIFYNQQNE NYFDNFFDSW FNFTVLQTTS NFPDVMMQYY NEHRWAPIVF VTFLLINLIL
     LLNTVLAVFY SNYKKEMEND TKKFFFKNKE KIHEYINKYI ITNPNKALSK QNQQLLQSFL
     KFHVRNQHFS ASEQFKLSQD LEIKTYSKSW ILRLFRSFQW NIFTGCLSLF NFTVLYIMVP
     SLSQKTDLDL WANVNFCINL VYFFEQLIQL IIFSKKYFKV KKYYIFDFFA SIVIITLLLI
     YYFTGEDSVL PYCMYLICTR LIRFIFILFK FESIKTIFRT VYEFVPLFVN LFGVLIIMFF
     FFSALGQHIF GGKMTYSYQA QIDEELHTEY YVLNNFNDQA TSLVLLFELL IVNNWMLNVQ
     AHQIIMGTKN VRYFFILWYI VSVVVCMNIM VAFIIDHLVN KFNDSDNQND SAYNYVQQQI
     HEQKQLNKQH SLKFSIFSQQ SEDIFQEQRN TLPHNNDFSK QSIQALDEED EEEEGSYE
//
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