GenomeNet

Database: UniProt
Entry: I7MDQ0_TETTS
LinkDB: I7MDQ0_TETTS
Original site: I7MDQ0_TETTS 
ID   I7MDQ0_TETTS            Unreviewed;       842 AA.
AC   I7MDQ0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Elongation factor 2 {ECO:0000256|ARBA:ARBA00017891};
GN   ORFNames=TTHERM_00706400 {ECO:0000313|EMBL:EAR90725.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90725.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step
CC       during translation elongation. During this step, the ribosome changes
CC       from the pre-translocational (PRE) to the post-translocational (POST)
CC       state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound
CC       deacylated tRNA move to the P and E sites, respectively. Catalyzes the
CC       coordinated movement of the two tRNA molecules, the mRNA and
CC       conformational changes in the ribosome.
CC       {ECO:0000256|ARBA:ARBA00024731}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG662794; EAR90725.1; -; Genomic_DNA.
DR   RefSeq; XP_001010970.1; XM_001010970.3.
DR   AlphaFoldDB; I7MDQ0; -.
DR   STRING; 312017.I7MDQ0; -.
DR   EnsemblProtists; EAR90725; EAR90725; TTHERM_00706400.
DR   GeneID; 7840201; -.
DR   KEGG; tet:TTHERM_00706400; -.
DR   eggNOG; KOG0469; Eukaryota.
DR   HOGENOM; CLU_002794_11_2_1; -.
DR   InParanoid; I7MDQ0; -.
DR   OrthoDB; 143042at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR   CDD; cd04096; eEF2_snRNP_like_C; 1.
DR   CDD; cd01885; EF2; 1.
DR   CDD; cd16268; EF2_II; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.240; -; 1.
DR   Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR42908:SF3; ELONGATION FACTOR-LIKE GTPASE 1; 1.
DR   PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   4: Predicted;
KW   Elongation factor {ECO:0000313|EMBL:EAR90725.1};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000313|EMBL:EAR90725.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          17..344
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
SQ   SEQUENCE   842 AA;  94250 MW;  DC0ACFEAEC8EFD52 CRC64;
     MKTLQIEKIR ELMMNPNQIR NMSVIAHVDH GKTTLTDSLL ARAGIISENN AGKACMMDTD
     PKEQEMGITI KSTGVSLYYQ NTVNKQESII NLIDSPGHID FSGEVTAALR VTDGALVVVD
     AVEGVAVQTE TVLRQACQER IRPVLVINKL DRLFSELKDD YENIYQRLIK IIAKVNSILE
     MHENDSIKNY TLDPSLGNVA FSSGKQCWGF TLKTFARIYS QKFSTKEDIL MNKLWGDNYF
     NPQTKSFTQD AHLINNEGKK AQRSFIEFVL APLDKYYSAS SNADIETLSK MVEKLHISTI
     LTTAELDRLK QLEVQERIKK SMRAWLPLAD AILEMVQDHL PSPREAMKYR SMYLYEGPAD
     DEACTAMKEC NSEGPLMVYI SKMVPTSDLS RFYAFGRVFS GTITQGMKVR VQGPDYKPGT
     KEGLFIKTIQ RTFLMMGKQQ EAIESVPAGG TVLILGIDSA LTKTGTLTTS ESAHNIRNMK
     YTISPILRVA VSTPNQQDLP RLLEGLKMLQ QYDQLVQVEI DENTGSYVVA GGGELHVQIC
     LEKLNDFTHN SIKIVASQPT VSYRETISEK SSQTCLAKTA NKLNRLYGTC DPLDEALGSA
     ISDNKINIQE VNSQETINTL VNTYNWERED AKKIWCFGPL EKESTNCIVN LTVGIQGMPA
     IQPSIITAFE WCTKEGLLCD EPLRNTRFNI TDAVIHIDPA HHRSNQITPA ARRLFKACQY
     VSEPKILEPF YQCDIRIPDD SKGPIYAVLN KRRGIVVGEE YEEALSMIQA HIPVSESFGL
     DQALKSATQG KAIPALSFSH WQVVQGNPLD PETKSGKIVT EIRTRKGLTA KIPELNNYLD
     KL
//
DBGET integrated database retrieval system