ID I7MDR6_TETTS Unreviewed; 1257 AA.
AC I7MDR6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=TTHERM_00142230 {ECO:0000313|EMBL:EAR90816.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90816.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677}.
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DR EMBL; GG662793; EAR90816.1; -; Genomic_DNA.
DR RefSeq; XP_001011061.1; XM_001011061.1.
DR AlphaFoldDB; I7MDR6; -.
DR STRING; 312017.I7MDR6; -.
DR EnsemblProtists; EAR90816; EAR90816; TTHERM_00142230.
DR GeneID; 7827489; -.
DR KEGG; tet:TTHERM_00142230; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_2_1; -.
DR InParanoid; I7MDR6; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 1136..1152
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 147149 MW; 56DAE76399963D4E CRC64;
MSPNKKTIKQ DVLFQEQTEK KKDSRSSSSK KKKNVEELLC RNLNIKDPKQ KQQKSSKKKS
NEHQQSQENQ ESQETNKQET NIFKDVFEDE QWQENNQNSL DFENENILDL IKNYTFAKQN
IKSQNLQQSN QKNGDKNDKK ASLNKQQISD SQKKQLNEME MEIENEGLSV STKTSGQKQK
NIYSDEIDSE EEIDLNDSLN KRKKLKKVTK DQIFEKCNKQ QQAILQNVEL KALKYPLEKE
QGEESDSFDE NIQKIDNKEQ GAQNEEIVDE TDVGELPEFL QKENIKDKKG NKIGSENYDP
TTLFIEESQL KIFKPYMREY WRIKSDHYDK IVLIKLGRFY EAYYEDSFVC NQILQPKYSR
KNKCGFPEEI LYPYLSKLTE CNLKVVIVDQ LETEKQQKER IKQMKSQNIK LTERDKLMNR
DVVAIYTKGT AALQLVRGRK LQLSTSTYIL SIVTEKQSFS KKITFGLTLF DSITGKILLA
CFEDDNIYST FQKIIYVYRP SEIIYRKQTT DIESLRLLSQ LPTKPLTTQL NEETIWKPTY
AFNHIADIFG SDDIQNMWPK CLYFYSRSEE NPSYQLTYSA LSALMYYMKS NLLFDETIPI
ANFIRIDHEN NREISDYELK ESNCDYKIEE GEQINSLHME QEDVQKQEDN NYEDKRLIMD
SQTLSNLDIL EVSYGNKESN FLLKQYSLLQ LLDRTCTKPG ERLIKLWVAS PLIDKQQIEQ
RLDAIEDLQN HNLLRDQFRD KLSNLSDLEN ILSRLYSYRV KNKSRGVYFE DVSQQRLREL
KNFFEDIKQI LITIKDTFFL ESNTFKSKRL KMLVGGNKKD ENYNPNDNLH DICLRKILSI
EKKILWIGSK KHIPTPVPGI CEAYDNKLKE IEDHENEFSN YIKKIRKQFG DDRIQFCHSK
APYQLEIPIE LVKGDKKPAD FELTSITKKT QRFHTPQLKQ LINKQLLLQD QLKQFLGDFT
CVIFDEFFKY RNNWNQIVNV IAEIDCLISL SQVSFHETMV QKLGFMTRPV IVDQKQDESN
YLKIIQGKHP CVALKKQFQA NSIIINTQHN KINYPRVQII TGPNMGGKST ILRSASLIVI
MAQVGCYVPC QYLEFSPFDR IFTRIGMRDL LSQGKSTFYI ELEETLQIVK NSNQNSLVLI
DELGRGTSTY DGVALASGVL QYIIEKNKSC CLFSTHSNFL VEQYQNSPMV KLFKMGYELV
PNEKNQIKFT YKLCDGQVEQ SFSRNVLDIV GFEKSLIFES HFRSCLINLS LMNAQNH
//
