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Database: UniProt
Entry: I7MFM3_TETTS
LinkDB: I7MFM3_TETTS
Original site: I7MFM3_TETTS 
ID   I7MFM3_TETTS            Unreviewed;      1157 AA.
AC   I7MFM3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   25-OCT-2017, entry version 35.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR84038.2};
GN   ORFNames=TTHERM_00760850 {ECO:0000313|EMBL:EAR84038.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84038.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662440; EAR84038.2; -; Genomic_DNA.
DR   RefSeq; XP_001031701.2; XM_001031701.2.
DR   STRING; 5911.EAR84038; -.
DR   GeneID; 7839898; -.
DR   KEGG; tet:TTHERM_00760850; -.
DR   InParanoid; I7MFM3; -.
DR   KO; K21867; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    355    374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    394    411       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    457    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    497    522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    547    567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    592       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      726    793       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      640    667       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1157 AA;  136064 MW;  B8C69A755178ABB6 CRC64;
     MRRPIFQDNQ TSLDQKKVNE SYSLAQQSSQ RTTFRELNSS EIRHQPFVYA SDFVKPALGD
     TNARDRDLVA DDLSQEDVKS NNLESYQGSF FYEIKMSKDK NFQSHQNSIF HSRYNVNSNT
     QSQSILDQIQ LNQQHQSPQS QVTNSQVIKE TEEVRNTQSI RMNDNASRQT PNRKKTSFPK
     VSSKKLTKYG ENARKSNLFT ELQLLKLQSE DKSVVNITRK SNQIMDIGLG GKFIQKAYLV
     YNFISKLKKN CGFYRPDTLN DNQRKLIGDL SNINTPAQNL WPNKQTDTEE SLDIKRQSQN
     IKNQSMRSGN LLNIRKHGST AFIANHINSI YSLAQRSSFF QKVCEIPTFS PHSKILDVFE
     IIQVVMSLLC IVYLPIEVAV KQTFYDLYGY KWEWFILSSI VFFVLGLLLN FNRGFYDKGL
     IVMNRRAIAK LYLKTGFLYD FLSMVPLVLS YLGVTGYLQF INIFVFLRLK NIMHFFQKCN
     SKFTSNNWVN LIVLLKLTRI ILTILFQAHI FACLFLGLYI HIDSKVNWVT RYNSSPVQLE
     GDWFIKYIYA FYWAITTMTT VGLGDLAPAN TIEVICYTIF MMSATCMFAY YFNAIGIVVQ
     ERNKISKQLS IEMTKTLRFL QSKQIEPEIQ YEVRRYLQYK YSAQKNMISL EEEREILEKL
     NPEIQQKVLF SANIKIIECC QFLKDNFSYQ FISKLAVKVK SQHYLNDQYI YHEGLSYYDE
     STEKKLYFIE NGKVQLLNEN QITGKVHLAN TLQRGDVFGQ FEFFSNQDYS MSAKTMEPVK
     LLVIEFNEFY QLIKDFPTDY EQFCMIRDKF QFQSRQNLQI KCESCGSLYH DILQCQKIHF
     VPNKELVILK NNFSQPIVQR KKRPDEERNI QVNALCQNQI VKQSIREYQE ENGIEFVKEE
     TPFTIKRLNL NNEDFAITPT NQKYNEFSSH RHQIQIPVFN SSSNQSKRPL QNNISQMLDD
     GEHTKRNQNF DNIEHSSITQ KGFGDFRKSQ LQQAQDEVKI NEYQFKHSNQ FYKFKASKNI
     NSEALSATKA GQHHKQIMRK SSYLNNMPQL HDQNLKKSQI QDEMQYNFVI QSSPFIPDYT
     FTSLTSKNDV FETMKEFNIY FPHNNYSNEI NKYNSSLKKI FNHIRNQTYH LYFRNKRILI
     DQQFLKNLNS NQEITYH
//
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