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Database: UniProt
Entry: I7MHB5_TETTS
LinkDB: I7MHB5_TETTS
Original site: I7MHB5_TETTS 
ID   I7MHB5_TETTS            Unreviewed;      1401 AA.
AC   I7MHB5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   05-JUL-2017, entry version 38.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAS02796.2};
GN   ORFNames=TTHERM_00348860 {ECO:0000313|EMBL:EAS02796.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS02796.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662523; EAS02796.2; -; Genomic_DNA.
DR   RefSeq; XP_001023041.2; XM_001023041.2.
DR   STRING; 5911.EAS02796; -.
DR   GeneID; 7836832; -.
DR   KEGG; tet:TTHERM_00348860; -.
DR   InParanoid; I7MHB5; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    224    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    338    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    379    402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    414    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      520    622       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED       44     65       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1401 AA;  163896 MW;  ACA0F05AB2619F87 CRC64;
     MYFFYFIYIQ IIIQMSLIYQ QIKDDEDFQA LRVRKESSIH SENMKESEDE ENTQKKNNKD
     EETNKERSLH INIQKNQQTS TFINDLTEGK MTKYSPMLSP QKDNPNLGFD GEIHSIYQGS
     GFLKGYKKNP KKLMKAINLL VNVKSFYNQL TKNTRIFQKL TQEQYILIGD NASFYTNRRV
     QKFSNKKISH YLQLFQQGIH ETLRFFQMIP IIQPHTAIKT LWDFFQGVVA LIFFGFDMLI
     QFNTGIVIKG QVEQSRVQIA KQYLRENFIM DVIGITPIFL LNSSHLNEAL TQSSSIIQNI
     LYACVIFKCF MLLSIYERIE QKFGYQKNLE NFFDLIKLLF KIGSICHFFS LLWFALGQYE
     IHILGKSNTW IQYKSIQDAG IFTQYIYSFY YITTTMITVG YGDITPQNEI EITFSVLIMY
     LTSVVYAYSL NCIGNILYNI NESHKDFRSD MRTIHQLMEE QNVKQSVRVK ISNYVEYLCK
     ESNHQKKAKQ DQILSKLSHQ LRSELMNEIK GKFISEIPLF KDIIQQQTIA KIIENMEECL
     FSPGEVIFQH HDQDDCAIYY LLKGQVKISL EDQVHRTVKL IERKGCFGEL SFITGNERIG
     TATANDFCRS YKIKRENFLD IIKQNSQDFE NFKMLYESVC LKGNLKFAKL YCYSCKRGDH
     TAQMCPKTHL IFSKQILIQK YNKSEPITKR TNHSRRKIRY NSKNLYQQVQ EALVNIHLVP
     EYEEIIQIIE KIAHLNDTFL ELYYSEEELS NCDAVSNNFN MSLKEIQQAS HREKLSNFQN
     EAYDQSQSRE LIDKNNLTPS QSSESDYEDN SISNSQSSSR ETTTIEVNSQ KENSQKQNKS
     KKRPRSTRSF AYEMNENIIQ ESSDESGEDE NQNGNKKINY NNQVIKWASK FNQQSEMSAF
     SVKEQNEDFQ FDDQSRKYLK DLEDEFFQKN QDYQNRSSYF QKSRQSMKSI NQMNQSSPNV
     FPKRKSYHKD YSEKSINQLH NQENDSQYMF KNLSSSPIYG HIDNKSYHNQ QSGLSNVVHY
     QNQSIVGFGD FNMSDQNIED LDQTREKKSN SVSTSKFNKD NISGKQAVGG YRKSVSFDPD
     NFQEMQKEYI KKQITGSVKR LHSQRSQEQS QRPYKPPSSS FQKIPSVLKN QSSLAIYHSS
     FNNTQSNILS NQSSQLRKQS TKNFKRQSTN INQSYSNMPS SSPGQQQQTQ KGILKKHQNE
     RRQLKPNDMR LILQNEEKLI ELYQNQQQQE QDEEQLISVK YKHSKLNQDF EDDKFDCMKN
     YVYYYPQFNA PIVISNYNQH LNKAQNGLKR RVTIQGKNLK SRIKRVINTK KGQNTPFSGN
     LVSPTPLLLS NAAIDKGTFQ QLGDKSTKTI QYYNNTHIQT NLIQSTEKII SAADTNINSS
     KFGLSTVLQY MKDKKQESKK Q
//
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