ID I7MJS2_TETTS Unreviewed; 1002 AA.
AC I7MJS2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:EAS07134.2};
GN ORFNames=TTHERM_00683400 {ECO:0000313|EMBL:EAS07134.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS07134.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662247; EAS07134.2; -; Genomic_DNA.
DR RefSeq; XP_001027376.2; XM_001027376.2.
DR AlphaFoldDB; I7MJS2; -.
DR STRING; 312017.I7MJS2; -.
DR GeneID; 7839169; -.
DR KEGG; tet:TTHERM_00683400; -.
DR eggNOG; KOG2076; Eukaryota.
DR InParanoid; I7MJS2; -.
DR OrthoDB; 379736at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR039340; Tfc4/TFIIIC-102/Sfc4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23082:SF0; GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3; 1.
DR PANTHER; PTHR23082; TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 154..187
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 918..951
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..463
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..512
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 118782 MW; E4ED52EF324715B7 CRC64;
MSNNTKREYQ DDDDEEHDSD LMSDFSDEEK RHKDLKSQFK GQRQQKIPQQ ISQLISDANS
KYVFQNQIDE AIEIAKEIIR QYPSFTDSYD LLGNIFEEQG MMKEAAEYQF LAAYQSNANA
KKWEGIAQLY KKAKCYDSAG YCFGRVLKSD TLNTSLWCER AKCYEQTGEL KKAIKCFERV
IKMDEKNFDA IKNCAKLYLK LDKSDESIKL LKTMIKPNDM NKNYNIIHMI CEIFNKKQQY
KELCEFLEEY CEMKDKNVRE TILDELPLAI LIFYAVSHAK LQNKEECELG FNLILRREME
ENDDFVSIME ELAEMYESSK EEEKALQIYK RLISLPFLQM NYQQVWEKYG TLLLKLHENE
ESIKEIEEII QKFPDSIDLR TELSSVYQSL GRNQDSLKIL ENLLRDDIEE NDFETRKQSD
EINLDIKEED IDRYSYTASY QDENNDEDEY IYQNDDDDED DENYQDRIKV DKKNIFDRFY
LDKSDQKKTK KEIGVDNDDN EDQDAGDDDS DFNYEEEQHK RVSQKKQASK ISGQYDQMRE
QNEIKPMKKK KLNSRVEKKI KNQMDDEKDD EIFQINKYQQ KDFFEQTQAK KNELAQHYSV
KNMYLEYKKG QIILDTTKEI SKHKLDKQFQ TLKQSLQLEK EYNNLKKSVL NRILIESQKK
GFQRRLTTPN NLKTFDNPNQ TLLIKKKRQM EEQEILMKKK FKKSEELTAK YLQNVEVLSL
KVGHEEYIQY LIKMLKVLVK YDCYVKISKI CSLAHKLHVW KDIRFFGYQE TVAKYGLLAT
LKLENYDKAF TYIKLLINRN SDRLYLQVIL CIIMRHISNV NIYKTFLSRM VKKSDDSPKF
LPIVACGFLE TGNFDLATDV LHTILKNDKA NSLCNLSLSV CYAQLTTART TYEKEQMAAK
AVHYMQAYQQ TRGLTRQMEI YYNLGRFFIH LSMNEKAIEN FENCIQLFSS KNLKGSYTLN
PKSKETDEKI LQKAIYNLIL LHKNLGNYQI AQSLLRQYNT LS
//
