ID I7MKI9_TETTS Unreviewed; 849 AA.
AC I7MKI9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=DEAD/DEAH-box helicase {ECO:0000313|EMBL:EAR99356.2};
GN ORFNames=TTHERM_00131240 {ECO:0000313|EMBL:EAR99356.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99356.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662639; EAR99356.2; -; Genomic_DNA.
DR RefSeq; XP_001019601.2; XM_001019601.3.
DR AlphaFoldDB; I7MKI9; -.
DR SMR; I7MKI9; -.
DR STRING; 312017.I7MKI9; -.
DR GeneID; 7829290; -.
DR KEGG; tet:TTHERM_00131240; -.
DR eggNOG; KOG0347; Eukaryota.
DR eggNOG; KOG3358; Eukaryota.
DR InParanoid; I7MKI9; -.
DR OrthoDB; 180020at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR PANTHER; PTHR47959:SF1; ATP-DEPENDENT RNA HELICASE DBPA; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EAR99356.2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 39..215
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 530..679
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 294..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..421
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..472
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 99670 MW; F96BCC7554131C32 CRC64;
MSHQTNQDWS KWDLIHPQVL QSLKDNNFNN PTEIQAYVLN TYRNYNDFLI ASQTGSGKTL
SFGIPIVSEI LYDKSGAFAE KKKDQKKKEK YIRCLIIAPT RELVLQIEKH LNQISQNSKD
QIRIGSIVGG ISKEKQRRIL SYVPDILIAT PGRLWDMIDN YEHECLEKLY MLDYLVLDEA
DRMVELGHFD ELDKILEKVY NKGEIVENKA DIQRLNQLIK EKKTKTIQLR TKAELPQSSK
NKLDQVGENE VMTLSGDEAK KFFASLRKNN QLDQNELKGI NLDFLDDENY INSTQDKESQ
EGEEDEEDFE DVDDDEEEEA DEEEEADEDE DDEEEEEEEE EEDDQEEQNE NELENQEDEE
SGNEIDEEED EENEEDQESE NENQDELNEE GDHNENEDEL DDQELEGEEE NEQEGEEDLE
NLEGLNLEKP KRNTKLKVFL VSATLTKQFA GNKHKVKALS KKEKKKLNKE KKEKKKSKEE
EKEEKMIPKM EALMNKVKFS GKYKVIDLTQ TMLIPKNLKE CKTVCVEEDK VLYLYHYLQQ
RPTENAIIFT NSISYAKKIV HLLEILGMKV LCMHSEMQQR QRLKKLDQFK NGQYSILVST
DVAARGLDIP SVQNVVHYQV PLDIDTYIHR SGRTARIGKA GTCYTLIGPK DGQRFQKIIK
QLDKEQGIQN IEINHTERDK IRVLIDSAQQ LEKSDFLVRQ KQVEKAWYSK NAKLAEIEVD
EEIKNELNII KEDLSKKRVV MKQDRVEFKK IKEDIKQIHR RPNNMFLEPS QIQKYLERIE
QLKASKSKNK SQQKEQNKQQ QQQQQQQPQQ KHGKGNKFQK FNNKNKNNNQ NKNNNQPDKF
NKKRRNSQR
//