ID I8II96_ASPO3 Unreviewed; 1464 AA.
AC I8II96;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=Ao3042_05359 {ECO:0000313|EMBL:EIT78361.1};
OS Aspergillus oryzae (strain 3.042) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1160506 {ECO:0000313|EMBL:EIT78361.1, ECO:0000313|Proteomes:UP000002812};
RN [1] {ECO:0000313|EMBL:EIT78361.1, ECO:0000313|Proteomes:UP000002812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3.042 {ECO:0000313|EMBL:EIT78361.1,
RC ECO:0000313|Proteomes:UP000002812};
RX PubMed=22933657; DOI=10.1128/EC.00160-12;
RA Zhao G., Yao Y., Qi W., Wang C., Hou L., Zeng B., Cao X.;
RT "Draft genome sequence of Aspergillus oryzae strain 3.042.";
RL Eukaryot. Cell 11:1178-1178(2012).
RN [2] {ECO:0000313|Proteomes:UP000002812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3.042 {ECO:0000313|Proteomes:UP000002812};
RA Zhao G., Hou L., Wang C., Cao X.;
RT "Comparative genomic analyses of Aspergillus oryzae 3.042 and A. oryzae
RT RIB40 for soy-sauce fermentation.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIT78361.1}.
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DR EMBL; AKHY01000138; EIT78361.1; -; Genomic_DNA.
DR HOGENOM; CLU_001331_1_0_1; -.
DR Proteomes; UP000002812; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204}.
FT DOMAIN 609..682
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 876..936
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 89..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1464 AA; 160960 MW; 37BB68914C273E7C CRC64;
MLREELLRSK NDEIARCLLS RKRKLSELYF ATVGFAGATE NPSADSLYHQ KEQAFLDAND
LSKGRYFDEA TLPPLPNYAE ILSRKYQEAV QSRPEPSKAS NAIPISPPAG GEAVVAQTAP
DAGKKTSLPR PLPEQKPPGT VLQQQQQEIQ VPTQPAPGVT PEGLPGLDAS TPVAAPPTES
PAPEQKVISA VPGTPKSSQG HDSTEVSISP SQAKPTTTTG VSSGPTDVSS VQKKPDERPS
LVLSRVAHRN EQPLSPVSSA GPYSNNTPVP VAVSPETSPA EEGPDPTDKI VPSPKPEEPT
QAPPILVPST PDEQLRLEEA QSLRQSSLVA KNTIGDSGTN EPSTNEVLQE SVAAPTDLEA
SLKEEQVSVA TPLAPESKKP DGVVQLAEDD GPPPSHQAEQ VQPSNAIEPK VLPPATSAQK
KVTQTVSGPA QPERMTTRVS SGAIRHKSVS EILGEAPKPV VAQPDKASAT DKPADTARAV
SKAPSDSAAR LSFKDRKARE RERSKLSTVV FPKQQQQQLQ DQADSMDLVR QHTGDLAKLN
EERDYLFTLF QSKAYSPPRG TSLSTLLASA HKTLTTANHH LEYQEQMDCR TLRRIYQLQN
ANRWPLRQMK RSAEPPRQGT HWDVLLDHMK WMRTDFREER KWKIAAAKSC ADWCAEYVNS
QPEHRSLLRV HSRIPPLKLV KKVEPDTNMM SPPEETGDEM LGLSHPTPDL VPSTEEDSVS
EGYNDEPRHD LHDTVAPAAI FSLSSDEFTF SLDMTPAAQK LLDELPVYSP VGIAPETNLP
TFKEPPDAVW KTEILPVSKY ASGKIAFLDD EPPRKRSRYD YSQYQSDPEQ GLLDLPPEQT
NVALFRPENK HIRDRIHPGH TFRPPTEYPM PSVGFFESRQ SSQWTYAEDD ELRRLVKEYS
YNWSLISSCL TPSSQFTSGA ERRTPWECFE RWIGLEGLPA DMSKTQYFRA YHQRLETAQR
TVLAQQQAAQ QQQQQQQQQQ QQQGNNNPQS LPPVRRRTTQ PVRVDRRRSS KHLALLDAMR
KLAKKRETML QKQQHASQLA SLRKVNEANQ PKPPISTPAE FSRLKYEREL KLQERQEQYR
QQMIATQRAN LAAQRAGQMP NQQPMMNAPG RTPNAMPQNP GTPSMPSSTP NGMPNGLPNG
MPNGIPPGVG ANQGRPHMQA MPNSGPVNGH MPPNPMAMKM MPQSGMQQTT ATRPGMPMQT
TPDNTRVIRE ANRLQEQQRL LQSRQQQQNP QPQPQQPQQQ FHNQQQFVGQ GSHSPNMNVP
NVNGTPNNPA MMAALQAGGG MQSPSFHNAT PQGVSTPSPR MGQPNLLSSG VVPTISSLQN
QIQRTHPGMS AEQVNKLATE RLHQYQQQRM SQVAMNAAAG NIGAVQANYQ MSQDGNFQSP
QNGMNGGPGI QMPQTQGYSP MMRVPQTAQQ NRVGVGNSPA MNGAVPQPSR SATPQTQRSG
SVQGGPMPPS NKSPNPPQAQ TASS
//
