ID I8R128_9THEO Unreviewed; 867 AA.
AC I8R128;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=ThesiDRAFT1_2331 {ECO:0000313|EMBL:EIW01183.1};
OS Thermoanaerobacter siderophilus SR4.
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=880478 {ECO:0000313|EMBL:EIW01183.1};
RN [1] {ECO:0000313|EMBL:EIW01183.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SR4 {ECO:0000313|EMBL:EIW01183.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Pagani I., Hemme C., Woyke T.;
RT "Improved High-Quality Draft sequence of Thermoanaerobacter siderophilus
RT SR4.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CM001486; EIW01183.1; -; Genomic_DNA.
DR RefSeq; WP_006570425.1; NZ_CM001486.1.
DR AlphaFoldDB; I8R128; -.
DR PATRIC; fig|880478.3.peg.1316; -.
DR HOGENOM; CLU_002472_4_0_9; -.
DR Proteomes; UP000005110; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 691..707
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 617..624
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 867 AA; 98941 MW; 488288D80CBAFB6B CRC64;
MAVTPMMEQY LKIKEKYKDA ILFFRLGDFY EMFYEDAEIA AKELEIALTG RDAGTEERAP
MAGVPYHAAD FYIDKLIKKG YKVAICEQLE DPAKAKGLVK RDVVRIYTPG TIINPESMDE
KTNNYLVSVF KGRDNYGICA VDVTTGDLYA TELKNCKDIK RVYDEITKYA PSEIIANEDF
LKNNKYIKIF KNNNCAVNIY EKQLDYEEKI KLIETQFNKK SEELGIKDKL YMANSLATLF
SYLQELQKTA LKHINKLLIY EDNSYMGLDS NAIKNLEILE SNRNKSKKGS LLGVLDKTVT
PMGGRLLKKW LEEPLLNKEH IDARLEAVEE LFNDYKNRQD LKQFLNKIYD LERLASKIVY
QSINPKDFIS IKLSLQNLPY IKEILEKFNS RLLKEICEKF DTLQDIYELI DKSIKDDPST
QLKEGNIIKD GYNETVDKLR KASTEGKNWI ANLEAEEREK TGIKNLRIGY NKVFGYYIEV
TKSNIPQVPE RYIRKQTLAN AERYVTPELK EIEETILGAE EKLIELEYQL FNEIREKVEL
QIVRIQNTAK YIATIDVLIS FAEVAETNRY IKPIVDYSDR IVIKEGRHPV IETISDESYV
ANDIDIGPEN PIMIITGPNM AGKSTYMRQV ALIVLMAQIG SFVPASYAKI GIVDKIFTRV
GASDDIFAGQ STFMVEMSEV ANILKSATSK SLIILDEVGR GTSTYDGMSI AHAVIEYIHE
KIKAKTLFAT HYHELTKLEG KMRGVRNYNV SVEEREDDII FLRKIVPGGA DKSYGIQVSK
LAGLPYSIVE RAKEILNSLE SDKVIKSELE NASQQLAFTQ IDIFSTAKDS LIDDIANCDV
DNMTPIQALN YLYELKEKAI SLRSGVL
//
