ID I8W068_9BACE Unreviewed; 672 AA.
AC I8W068;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=CBM6 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1062_02243 {ECO:0000313|EMBL:EIY32060.1};
OS Bacteroides cellulosilyticus CL02T12C19.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997874 {ECO:0000313|EMBL:EIY32060.1, ECO:0000313|Proteomes:UP000003741};
RN [1] {ECO:0000313|EMBL:EIY32060.1, ECO:0000313|Proteomes:UP000003741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C19 {ECO:0000313|EMBL:EIY32060.1,
RC ECO:0000313|Proteomes:UP000003741};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides cellulosilyticus CL02T12C19.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY32060.1}.
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DR EMBL; AGXG01000051; EIY32060.1; -; Genomic_DNA.
DR RefSeq; WP_007216948.1; NZ_JH724086.1.
DR AlphaFoldDB; I8W068; -.
DR GeneID; 66306324; -.
DR PATRIC; fig|997874.3.peg.2298; -.
DR HOGENOM; CLU_019255_0_0_10; -.
DR OrthoDB; 9801455at2; -.
DR Proteomes; UP000003741; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04084; CBM6_xylanase-like; 1.
DR CDD; cd09001; GH43_FsAxh1-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR005084; CMB_fam6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF13; HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED; 1.
DR Pfam; PF03422; CBM_6; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 348..534
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT DOMAIN 554..671
FT /note="CBM6"
FT /evidence="ECO:0000259|Pfam:PF03422"
FT ACT_SITE 60
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 223
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 169
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 672 AA; 76475 MW; 45150A34FD31C3B5 CRC64;
MYNLSITTGK IADGFSALLM LCCILMVQSC TVPVQTTASL SSDNGDGTYT NPVINADYPD
PDIIRVGEDF YMVSSSFVAM PGIPICHSKD LINWRIIGHA YDSITFRPQY RMENEQTAYS
RLCWAPSIKY HDGTYYIGVN IADDGFVMFK SNKPEGPYSM HKFDKRLYDP GFFIDDDGKK
YVTHGKTKIY LTRLKDDGTG VLYPNDEGTL IITAPKGYEY LFEGCHTYKR NGWYYIFNPA
LGYNGVQMIS RSRNLYGPYE TKVLIDDDIN YADAGVHQGG YVETLEGESW AYTFQDRDYM
GRCVMLYPMK WEEDWPVVGP EGKPGKGVVT YRKPAVKAKQ EITFPQHSDD FSSSKLAHVW
EFNHVPRKDK WSLTDRPGYF RIYAQYAKGF EWARNSLTQK VSGPYSTGTV SLDLTGLREG
DFAGNGIMGR VMYQLGVRKK ADGFWLEMRQ GGREGETVVD SLPVKTDKIY LRTEVTKQGS
LLFYYSLDNL EYNRLGPEGV SNFWGFLGIR HALCCYNLNK GATGGYADFD YFELESNRRG
NHYDAFTEID FSQYDDREGM KLVRPVAKRP MQFISGVRDG NWLVFNNMCF KQNPQKVTIE
LQAETPGTVI EIREGSLDGK LIATCPINQN QTPGEWEKQA FEVSGAVKDK SKIYFLFRGQ
SQGLAIKNFV FY
//