ID I8XPI5_9BACE Unreviewed; 393 AA.
AC I8XPI5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=5'-deoxynucleotidase {ECO:0000256|ARBA:ARBA00012964};
DE EC=3.1.3.89 {ECO:0000256|ARBA:ARBA00012964};
GN ORFNames=HMPREF1068_01539 {ECO:0000313|EMBL:EIY51992.1};
OS Bacteroides nordii CL02T12C05.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997884 {ECO:0000313|EMBL:EIY51992.1, ECO:0000313|Proteomes:UP000003089};
RN [1] {ECO:0000313|EMBL:EIY51992.1, ECO:0000313|Proteomes:UP000003089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C05 {ECO:0000313|EMBL:EIY51992.1,
RC ECO:0000313|Proteomes:UP000003089};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides nordii CL02T12C05.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-
CC deoxyribonucleoside + phosphate; Xref=Rhea:RHEA:36167,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:18274, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:65317; EC=3.1.3.89;
CC Evidence={ECO:0000256|ARBA:ARBA00001638};
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY51992.1}.
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DR EMBL; AGXS01000015; EIY51992.1; -; Genomic_DNA.
DR AlphaFoldDB; I8XPI5; -.
DR STRING; 997884.HMPREF1068_01539; -.
DR PATRIC; fig|997884.3.peg.1565; -.
DR eggNOG; COG1878; Bacteria.
DR eggNOG; COG1896; Bacteria.
DR HOGENOM; CLU_701425_0_0_10; -.
DR Proteomes; UP000003089; Unassembled WGS sequence.
DR GO; GO:0002953; F:5'-deoxynucleotidase activity; IEA:InterPro.
DR GO; GO:0004061; F:arylformamidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:InterPro.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 3.50.30.50; Putative cyclase; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR InterPro; IPR039356; YfbR/HDDC2.
DR PANTHER; PTHR11845:SF13; 5'-DEOXYNUCLEOTIDASE HDDC2; 1.
DR PANTHER; PTHR11845; UNCHARACTERIZED; 1.
DR Pfam; PF04199; Cyclase; 1.
DR Pfam; PF13023; HD_3; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF102198; Putative cyclase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000003089}.
FT DOMAIN 38..153
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 393 AA; 45369 MW; 64631EED36E615C3 CRC64;
MLLLKTEMRM EPRELINFMA IAERLKCNTR HSWTSTYRHE SVAEHSWRLT LLAYFVQDEF
PEADMNKVIQ MCILHDLGEA ITGDIPAFYK TQKDEEVEDR KIEELFQTLP PFYQDKLLPL
FREMGELATL EAKIYKALDK MEAIIQHNEA DISTWIPLEY TTNLEYGAEN VAFSPYLRRL
KQELYNDSVR KIESVSEQGG GSNNRWVDLT LKVSPKMIKD AQGNENKAFT GHLGTHFDVM
NKEFPLNYTE RKAIVFDVSS ISGRDIEVQD IDLSKVRPDM FVSFYSGYIE RESYGSKAYF
SEHPQLSDEL IEKLLDRHIS IIGIDFAGVR RGTEHTPKDQ YCADKGVFII ENLCHLGQLL
VGDEKSAEFI ANTYPMNFAE MTGLPCRVIA KRK
//
