ID I8XVK9_9BACE Unreviewed; 604 AA.
AC I8XVK9;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Beta-glucuronidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1068_00166 {ECO:0000313|EMBL:EIY54945.1};
OS Bacteroides nordii CL02T12C05.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997884 {ECO:0000313|EMBL:EIY54945.1, ECO:0000313|Proteomes:UP000003089};
RN [1] {ECO:0000313|EMBL:EIY54945.1, ECO:0000313|Proteomes:UP000003089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C05 {ECO:0000313|EMBL:EIY54945.1,
RC ECO:0000313|Proteomes:UP000003089};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides nordii CL02T12C05.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY54945.1}.
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DR EMBL; AGXS01000001; EIY54945.1; -; Genomic_DNA.
DR RefSeq; WP_007482924.1; NZ_JH724314.1.
DR AlphaFoldDB; I8XVK9; -.
DR STRING; 997884.HMPREF1068_00166; -.
DR PATRIC; fig|997884.3.peg.183; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_009935_2_1_10; -.
DR Proteomes; UP000003089; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR42732:SF3; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000003089};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..604
FT /note="Beta-glucuronidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003716800"
FT DOMAIN 92..167
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 209..303
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 341..598
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 604 AA; 70012 MW; 8CED12FFD163E2DE CRC64;
MKHLIIYILS SFLLLTGWTA NAQNNSIPRP EYPRPQFERA EWRNLNGQWS YTFDFGKSGR
DRKLYNSTGF NEFIIVPFCP ESKLSGVEYK DFIPAMWYHR KLQVPADWQD KKVILHFGGV
DYYSVIYING QVAGRHWGGS SSFGIDITRF VKYGEEQQLV VYVEDDQRSG SQGRGKQSGN
FYSQGCDYTR TTGIWQTVWM EAVDACGLKS VRITPELDQK CFTVQPEFYG LQAGQKLRVS
VKDGDRVVSK QTQTAATPLT LMLPLKTVKT WSPDSPFLYD IELEVLDAKG KVIDHVNSYA
GMRKVHIEGN KFFLNNEPCY LRFVLDQGFY PTGVWTAPTD ADLKRDIELS LAAGFNGARL
HQKVFEERFH YWADKLGYLT WGESASWGLN TSSPEAARNF LTEWEEVVVR DRNHPSIIVW
TPFNETWDRP NDNEQARQHD RFISDVYKLS HNLDYRPVND ASGNYHVMTD IWSVHHYAQS
GEEMKKRLEI KDGKLPQKDV KKEVPYEGQP YFLDEYGGIK WVHGKQFAKN SWGYGQGPKT
LDEFYARLKD ITFTVLEFDF VAGYCYTQLT DVEQEQNGIY NYDRTPKFDM EIIKSIFNRL
PEKK
//
