ID I9AFI8_9BACE Unreviewed; 808 AA.
AC I9AFI8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Capsular exopolysaccharide family protein {ECO:0000313|EMBL:EIY86465.1};
GN ORFNames=HMPREF1074_01949 {ECO:0000313|EMBL:EIY86465.1};
OS Bacteroides xylanisolvens CL03T12C04.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997892 {ECO:0000313|EMBL:EIY86465.1, ECO:0000313|Proteomes:UP000003566};
RN [1] {ECO:0000313|EMBL:EIY86465.1, ECO:0000313|Proteomes:UP000003566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL03T12C04 {ECO:0000313|EMBL:EIY86465.1,
RC ECO:0000313|Proteomes:UP000003566};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides xylanisolvens CL03T12C04.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY86465.1}.
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DR EMBL; AGXE01000012; EIY86465.1; -; Genomic_DNA.
DR RefSeq; WP_008022759.1; NZ_JH724294.1.
DR AlphaFoldDB; I9AFI8; -.
DR PATRIC; fig|997892.3.peg.2001; -.
DR HOGENOM; CLU_009912_6_0_10; -.
DR Proteomes; UP000003566; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..113
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 450..525
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 593..723
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 808 AA; 90237 MW; AA814F21646E0532 CRC64;
MIGEKRENRG EQPEEQVDIQ EILFRYLIHW PWFVVSVIIC IACAWGYLRL ATPVYDITAT
VLIKDDKKGG GASMSSELEK MGLDGFVSSS NNVDNEIEVL KSKSLAREVV NNLGLFVTYK
DEDEFPNREL YRTSPVVVSL TPQEAEKLSA PMEVEMTLFP NGGMDALITV KDKEYRKQFD
KLPAVFPTDE GTIAFFESKD TLTTNQAKEE SKERHIKAFI NRPMSVAKGY IKSLSIAPTS
KTTSVAVLSL KNSNTRRGKD FINKLLEMYN INANNDKNEV AQKTAEFIDE RIGIISKELG
STEQDLENFK RSAGITDLSS EAQIALTGNA EYEKKRVENQ TQINLVMDLQ RYMQGNEYEV
LPSNIGLQDA ASAGAIDRYN EMLVERKRLL RTSTENNPTI INLDTSIRAM RSNVQATLDA
TLKGLQITKE DLAREANRYS RRINDAPTQE RQFVSIARQQ EIKAGLYLML LQKREENAIT
LAATANNAKI IDEALADDNP VSPKRMMVYL AALVLGVGFP VGIIYLIGLT KFKIEGRADV
EKLTSLPVIG DIPLADEKSG SIAVFENHNN LMSETFRNVR TNLQFMLENG KNVILVTSTI
SGEGKSFVSS NLAISLSLLG KKVVIVGLDI RKPGLNKVFN ISQKEHGITQ FLTNPTKNLM
DLVQPSDINK NLFILPGGAV PPNPTELLAR DGLERAIETL KANFDYVILD TAPVGMVTDT
LLIGRTADLS VYVCRADYTR KAEFTLINEL SENNKLPNLC IAINGLDLQK KKYGYYYGYG
KYGKYYGYGK RYGYGYGYGE KHTAREGK
//
