ID I9H2G0_9BACE Unreviewed; 1000 AA.
AC I9H2G0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=HMPREF1068_00814 {ECO:0000313|EMBL:EIY53644.1};
OS Bacteroides nordii CL02T12C05.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997884 {ECO:0000313|EMBL:EIY53644.1, ECO:0000313|Proteomes:UP000003089};
RN [1] {ECO:0000313|EMBL:EIY53644.1, ECO:0000313|Proteomes:UP000003089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C05 {ECO:0000313|EMBL:EIY53644.1,
RC ECO:0000313|Proteomes:UP000003089};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides nordii CL02T12C05.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC residues in alpha-D-galactosides, including galactose
CC oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing branched (1->3)-alpha-D-
CC galactosidic residues, producing free D-galactose.; EC=3.2.1.n1;
CC Evidence={ECO:0000256|ARBA:ARBA00001271};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY53644.1}.
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DR EMBL; AGXS01000011; EIY53644.1; -; Genomic_DNA.
DR RefSeq; WP_007483737.1; NZ_JH724314.1.
DR AlphaFoldDB; I9H2G0; -.
DR STRING; 997884.HMPREF1068_00814; -.
DR PATRIC; fig|997884.3.peg.824; -.
DR eggNOG; COG3866; Bacteria.
DR HOGENOM; CLU_004997_0_0_10; -.
DR Proteomes; UP000003089; Unassembled WGS sequence.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR026444; Secre_tail.
DR NCBIfam; TIGR04183; Por_Secre_tail; 1.
DR PANTHER; PTHR42970; PECTATE LYASE C-RELATED; 1.
DR PANTHER; PTHR42970:SF1; PECTATE LYASE C-RELATED; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS50853; FN3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000003089};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1000
FT /note="Fibronectin type-III domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003720609"
FT DOMAIN 474..569
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 411..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 109488 MW; 4AB73AB4CB2A09A2 CRC64;
MKNFTSIVGT FALALFPLLP VTAQSVTEPQ LAFPGAEGFG RYAVGGRYGE VYHVTNLNDS
GEGSLRDAVS QPNRIVVFDV SGVIHAKSVI PFAKNLTIAA QTAPGNGIVI YGNRVSFSGA
DNIICRYLRV RYGYEESPGG YVDAAGVAFG SNMIFDHLSV TWGTDECFSI NGDSKRPDDQ
PRNITIQNSI MGQGLWDHSC GGLMQTSDEN GITLFRNLYI DNKTRNNKVK GLNQFVNNVI
YNWGDGGAYI MGDTDAASLA DIQNNYFIEG KSERYLVRYN GGTPENPVTQ SFRPTVPFTR
AKPAFVTYFA GNYFDNNRDG KLDGRLLTRE DCNRYQPDSA IPEGGQQLTP TFLDGPSEKH
PVIGAKMTAE EAYHWVVDNV GAILPVRDEV DAYMIDELTS LGTKGQIIDT EMSLPTRGPG
EILRGVKLPD TDNDGIPDAW EEQNGLDKND PTDAMKIAAN GYANIENYIN SIDAPMPFLA
CPSTMEATAD HTTITLSWKD YSDEEEGYIL EQRDAQGTFA EVAKLPVNTT SHTVSDLTPG
VLYAFRLKAY NTTTESVYSD VLEVATKRLL VAPDQCIEPF PEIDAILSFN ASKDITLSWK
NETHPDNGVT TYKVYAGTEK NKLECISGAE AQEATSLTLK ADPSKTYYWR VDALNVKNEV
TTGTVWSFMT QTLDAKEPVM YLSLDGTLKN FADVAGAKDA ELVELEPTYV AGKNEQGLLL
ENVVTGSCIS VPYYEGMKFE GGSGTADPAA SFSVSMWVKS DGSCPVDGKG FLFHKGTFKD
SKGKARWCGA EIRNNELYFA VSQNGTKHEI KLVSGDVFKN IFNNEWHHLV FVRSHEEQAL
IAYCDGKLLG KRDSNRAYMN SEVGIVFGNV MEKLNEPFAG TLDELKLFRG TLMAEEVTNL
FETGNTAGIP TSINQELAIN SELGIYPSPF FNHFYIVVPQ EEVSVKICLY DASGRLALSR
EVKADNGTAY IGELNGLAGG IYVVSVETST GVITKTALKK
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