ID I9K7H7_BACFG Unreviewed; 649 AA.
AC I9K7H7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Alpha-glucosidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1080_02706 {ECO:0000313|EMBL:EIY95734.1};
OS Bacteroides fragilis CL05T12C13.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997881 {ECO:0000313|EMBL:EIY95734.1, ECO:0000313|Proteomes:UP000003917};
RN [1] {ECO:0000313|EMBL:EIY95734.1, ECO:0000313|Proteomes:UP000003917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL05T12C13 {ECO:0000313|EMBL:EIY95734.1,
RC ECO:0000313|Proteomes:UP000003917};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides fragilis CL05T12C13.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY95734.1}.
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DR EMBL; AGXP01000028; EIY95734.1; -; Genomic_DNA.
DR RefSeq; WP_005802544.1; NZ_JH724195.1.
DR AlphaFoldDB; I9K7H7; -.
DR PATRIC; fig|997881.3.peg.2854; -.
DR HOGENOM; CLU_011166_0_0_10; -.
DR Proteomes; UP000003917; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR029483; GH97_C.
DR InterPro; IPR019563; GH97_catalytic.
DR InterPro; IPR029486; GH97_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR35803; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED; 1.
DR PANTHER; PTHR35803:SF2; RETAINING ALPHA-GALACTOSIDASE; 1.
DR Pfam; PF14509; GH97_C; 1.
DR Pfam; PF14508; GH97_N; 1.
DR Pfam; PF10566; Glyco_hydro_97; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..649
FT /note="Alpha-glucosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003721683"
FT DOMAIN 25..282
FT /note="Glycosyl-hydrolase 97 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14508"
FT DOMAIN 288..548
FT /note="Glycosyl-hydrolase 97 catalytic"
FT /evidence="ECO:0000259|Pfam:PF10566"
FT DOMAIN 550..648
FT /note="Glycosyl-hydrolase 97 C-terminal oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF14509"
SQ SEQUENCE 649 AA; 74470 MW; C42B7088DAA7D66A CRC64;
MKKQLLLLLI FSISLYVQGQ NIHKLASPDG NIQISVNLSD KIYYDVICRN ETLLKQCHLA
MEIGDQELGT NPKMTKVSHK NIDESLKPVI PLKFSSVSNR YNQLLLDFKG GYSVEFRAFN
DGIAYRFITN KKGMINVKNE TLQVNFPDNY LLHMQQSGSF KTAYEEEYTH LYSKEWKSSA
SMALLPILID TQKGSKILIS ETSLTDYPAV FLKSNGSNGM VSVFPKVPLE FGEDGDRSVK
ILKEADYIAQ TSGKRNFPWR YFVISTEDSQ LIENTMSYRL AEKNILEDTS WIKPGLASWE
WWNGATPYGP DVNFVAGCNL DTYKYFIDFA ANYGIPYIIM DEGWAMSTRD PYTPNPAVDV
HELIRYGKEK NVGIVLWLTW LTVENNFGLF ETFEKWGVKG VKIDFMDRSD QWMVNYYERV
AREAAKHHLF VDFHGAFKPA GLEYKYPNVL SYEGVRGMEQ MGGCRPDNSI YLPFMRNAVG
AMDYTPGAML SMQPEIYCSE RPNSASIGTR AYQMALFVIF ESGLQMMADN PTLYYRNDEC
TRYITQVPQT WDETIALKAK VGEYVIVAKR KGDKWYIGGM TNNRQQERTF ELDFDFLKEG
QSYRMTSFED GVNANRQAMD YRKKEYTLKK GDKIIVRLAR NGGFASVIE
//
