ID I9PYE2_HELPX Unreviewed; 274 AA.
AC I9PYE2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN ORFNames=HPNQ4200_1657 {ECO:0000313|EMBL:EJB27411.1};
OS Helicobacter pylori NQ4200.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992024 {ECO:0000313|EMBL:EJB27411.1, ECO:0000313|Proteomes:UP000003358};
RN [1] {ECO:0000313|EMBL:EJB27411.1, ECO:0000313|Proteomes:UP000003358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NQ4200 {ECO:0000313|EMBL:EJB27411.1,
RC ECO:0000313|Proteomes:UP000003358};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594, ECO:0000256|RuleBase:RU362026}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB27411.1}.
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DR EMBL; AKNS01000012; EJB27411.1; -; Genomic_DNA.
DR RefSeq; WP_000867870.1; NZ_AKNS01000012.1.
DR AlphaFoldDB; I9PYE2; -.
DR PATRIC; fig|992024.3.peg.1591; -.
DR Proteomes; UP000003358; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370:SF32; DNA ADENINE METHYLTRANSFERASE YHDJ; 1.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EJB27411.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJB27411.1}.
FT DOMAIN 37..251
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 274 AA; 31438 MW; A7C0FD75F9368B90 CRC64;
MKVPCLSRPI FKSADRLFTL YQGDCNEVLP QFENAFDLIF ADPPYFLSND GLSIQSGKIV
SVNKGDWDKE NGINDIDEFN YQWINNAKKA LKNTGSLLIS GTYHNLFSLG RILQKLDFKI
LNLITWQKTN PPPNFSCRYL THSAEQIIWA RKSRKHKHVF NYEVLKKINN DKQMRDVWSF
PAIAPWEKTN GKHPTQKPLA LLVRLLLMAS DGNSLIGDPF SGSSTTGIAA NLLNREFIGI
EKESEFIKIS MDRKIELDAR YKEIRSKIKD LNLQ
//
