ID I9QRR8_HELPX Unreviewed; 939 AA.
AC I9QRR8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=pcrA {ECO:0000313|EMBL:EJB35749.1};
GN ORFNames=HPNQ4053_0035 {ECO:0000313|EMBL:EJB35749.1};
OS Helicobacter pylori NQ4053.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992027 {ECO:0000313|EMBL:EJB35749.1, ECO:0000313|Proteomes:UP000004260};
RN [1] {ECO:0000313|EMBL:EJB35749.1, ECO:0000313|Proteomes:UP000004260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NQ4053 {ECO:0000313|EMBL:EJB35749.1,
RC ECO:0000313|Proteomes:UP000004260};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB35749.1}.
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DR EMBL; AKNV01000001; EJB35749.1; -; Genomic_DNA.
DR AlphaFoldDB; I9QRR8; -.
DR PATRIC; fig|992027.3.peg.32; -.
DR Proteomes; UP000004260; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF67; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:EJB35749.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:EJB35749.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..417
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT COILED 253..280
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 5..12
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 939 AA; 108467 MW; 174C2629C50DC9D6 CRC64;
MALKASAGSG KTFALSVRFL ALLFKGANPS EILTLTFTKK ATAEMKERIL DYLKILQQEN
LESEKEKSQN ILKELEEKYH LDPSLVRNSA QKIYQRFLNA EIRISTIDAF FQSILRKFCW
FVGLSANFEV NEDTEAHQRQ LNEGFLSALN NEQLEELSVF IAQCLSYDNY TSDSILERLR
FLKNKLYLFD PNKREPAFDE EGFLEKLRSL NEQIQSIETA SDRAKTAIKC DSFRGFLNSS
LTWLEKKSEY QSFKKLKSEI PTLESECKEI ENDLKRYYEA KETAIFKKFP KFIQLYDNAT
SKIQALDFDA IKDKVHVLLN GYEEMPAEFF YFRLDSKIAH ILIDEFQDTS LNDYKILAPF
IDEIKAGIGQ AKWHRSVFFV GDVKQSIYAF RGSFSSLFES VSKDFYHDNL QFNHRSAPLI
INYVNTIFKK AYQNSPTAYL EQKYPKASNN KHVTDGYVKV SLVADERELL LEQILQEAQN
LLDHRIDPKD ITILCATNDD ALEIKNYLQE YLSAICPSTE SSARLSQFVE SKIIKNALKY
ALAEEPYKPF YKHSVLKLAG YLHDDAIVLP SFNPKKESVA SFVWKIMELF ELYEEPAQIC
LELAIGCEDA DGFLEKLEAK AIASFNLKGA QIMTIHKSKG MQFPYVIVCE RLGKPNSSHS
NQLLEEYDGA ELLRLYYRMK NREVVDKDYA RALNKEEAAK DHEEINVYYV AFTRAELGLI
VVAKDKKESK KESKNKTMHE KLDLLPLEEG EIMPVISPQK EPLITSALIK PHAYGEQVQE
IEEEPDSDYE KNNDQEAINF GIALHKGLEY QYAYNIPKKS VLEYLNYHHG FYGLDHQALE
ESLELFENDA EIQALFKNHA LKGEAAFLFE GVVSRIDVLL WDRGQNLYVL DYKSSQNYQQ
SHKAQVSHYA EFLRTQAPHF KIQAGIIYAH KRLLEKLWV
//