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Database: UniProt
Entry: I9QRR8_HELPX
LinkDB: I9QRR8_HELPX
Original site: I9QRR8_HELPX 
ID   I9QRR8_HELPX            Unreviewed;       939 AA.
AC   I9QRR8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=pcrA {ECO:0000313|EMBL:EJB35749.1};
GN   ORFNames=HPNQ4053_0035 {ECO:0000313|EMBL:EJB35749.1};
OS   Helicobacter pylori NQ4053.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=992027 {ECO:0000313|EMBL:EJB35749.1, ECO:0000313|Proteomes:UP000004260};
RN   [1] {ECO:0000313|EMBL:EJB35749.1, ECO:0000313|Proteomes:UP000004260}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NQ4053 {ECO:0000313|EMBL:EJB35749.1,
RC   ECO:0000313|Proteomes:UP000004260};
RX   PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA   Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA   Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA   Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT   "Genome sequences of 65 Helicobacter pylori strains isolated from
RT   asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT   disease, or gastritis.";
RL   Pathog. Dis. 68:39-43(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJB35749.1}.
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DR   EMBL; AKNV01000001; EJB35749.1; -; Genomic_DNA.
DR   AlphaFoldDB; I9QRR8; -.
DR   PATRIC; fig|992027.3.peg.32; -.
DR   Proteomes; UP000004260; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF67; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:EJB35749.1};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:EJB35749.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          1..417
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          253..280
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         5..12
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   939 AA;  108467 MW;  174C2629C50DC9D6 CRC64;
     MALKASAGSG KTFALSVRFL ALLFKGANPS EILTLTFTKK ATAEMKERIL DYLKILQQEN
     LESEKEKSQN ILKELEEKYH LDPSLVRNSA QKIYQRFLNA EIRISTIDAF FQSILRKFCW
     FVGLSANFEV NEDTEAHQRQ LNEGFLSALN NEQLEELSVF IAQCLSYDNY TSDSILERLR
     FLKNKLYLFD PNKREPAFDE EGFLEKLRSL NEQIQSIETA SDRAKTAIKC DSFRGFLNSS
     LTWLEKKSEY QSFKKLKSEI PTLESECKEI ENDLKRYYEA KETAIFKKFP KFIQLYDNAT
     SKIQALDFDA IKDKVHVLLN GYEEMPAEFF YFRLDSKIAH ILIDEFQDTS LNDYKILAPF
     IDEIKAGIGQ AKWHRSVFFV GDVKQSIYAF RGSFSSLFES VSKDFYHDNL QFNHRSAPLI
     INYVNTIFKK AYQNSPTAYL EQKYPKASNN KHVTDGYVKV SLVADERELL LEQILQEAQN
     LLDHRIDPKD ITILCATNDD ALEIKNYLQE YLSAICPSTE SSARLSQFVE SKIIKNALKY
     ALAEEPYKPF YKHSVLKLAG YLHDDAIVLP SFNPKKESVA SFVWKIMELF ELYEEPAQIC
     LELAIGCEDA DGFLEKLEAK AIASFNLKGA QIMTIHKSKG MQFPYVIVCE RLGKPNSSHS
     NQLLEEYDGA ELLRLYYRMK NREVVDKDYA RALNKEEAAK DHEEINVYYV AFTRAELGLI
     VVAKDKKESK KESKNKTMHE KLDLLPLEEG EIMPVISPQK EPLITSALIK PHAYGEQVQE
     IEEEPDSDYE KNNDQEAINF GIALHKGLEY QYAYNIPKKS VLEYLNYHHG FYGLDHQALE
     ESLELFENDA EIQALFKNHA LKGEAAFLFE GVVSRIDVLL WDRGQNLYVL DYKSSQNYQQ
     SHKAQVSHYA EFLRTQAPHF KIQAGIIYAH KRLLEKLWV
//
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