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Database: UniProt
Entry: I9R1I3_HELPX
LinkDB: I9R1I3_HELPX
Original site: I9R1I3_HELPX 
ID   I9R1I3_HELPX            Unreviewed;       597 AA.
AC   I9R1I3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   Name=sfcIM {ECO:0000313|EMBL:EJB40376.1};
GN   ORFNames=HPHPA4_1295 {ECO:0000313|EMBL:EJB40376.1};
OS   Helicobacter pylori Hp A-4.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=992032 {ECO:0000313|EMBL:EJB40376.1, ECO:0000313|Proteomes:UP000003633};
RN   [1] {ECO:0000313|EMBL:EJB40376.1, ECO:0000313|Proteomes:UP000003633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hp A-4 {ECO:0000313|EMBL:EJB40376.1,
RC   ECO:0000313|Proteomes:UP000003633};
RX   PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA   Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA   Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA   Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT   "Genome sequences of 65 Helicobacter pylori strains isolated from
RT   asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT   disease, or gastritis.";
RL   Pathog. Dis. 68:39-43(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJB40376.1}.
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DR   EMBL; AKOA01000007; EJB40376.1; -; Genomic_DNA.
DR   RefSeq; WP_000208605.1; NZ_AKOA01000007.1.
DR   AlphaFoldDB; I9R1I3; -.
DR   PATRIC; fig|992032.3.peg.1259; -.
DR   Proteomes; UP000003633; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   PANTHER; PTHR33841:SF1; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          66..308
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   597 AA;  69537 MW;  90186A3745BE29C3 CRC64;
     MTTKLSCKGL SRSIQRFHID DIEKSIVKYT IETINPNHTD LSLFASNHNE DIVNILRDNK
     TPICFDVFNA LFENLLDQER KTKFGMIFTP KYIADFICNE TFAKFEDLNN IKVIDPCCGC
     GIFLISAIEQ IKSKTKKSIK QIIKNQIFGL DIDKDNVKKV ILLLKIMGLV YNENIEDCDI
     NIRHCDSLIT DWKLAFDIDF DCIIGNPPYI NPHSLSKKQT AFLKQNFQTT SSGVFNIFYA
     FIELGMKFIK PNGFLSYIVP NNFFTISAAK PLRDFIEPYL CELIDFKDNM VFKPTRTYST
     IITLSLNDNK CIKYADIQKT NQVATYLDNI AYKMLDKKSV FGHKWRFLDF SVESNIKKIE
     NQFFVLKPFI NTGIATLRDE VYCVDFDGKF FFKNVNGKKY IIDSDLIKPI YKIPKFKNSK
     QSGYFIFPYT IKNNIATIID ERTMQREFSN TYEYLLARKN ELDLRDRGRA NPVSWYAYGR
     TQGLNKSGKK LLFSTFGAKP NFIFIDNKTA LFCNGYAIVE NDSIELEILQ KVLNSCIVQY
     YIQHTSYQID GGYFCYQKKY IEKFGIPYFD FKEKEFLLKA SPKEIDTFLI DKYEMIL
//
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