ID I9R1I3_HELPX Unreviewed; 597 AA.
AC I9R1I3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=sfcIM {ECO:0000313|EMBL:EJB40376.1};
GN ORFNames=HPHPA4_1295 {ECO:0000313|EMBL:EJB40376.1};
OS Helicobacter pylori Hp A-4.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992032 {ECO:0000313|EMBL:EJB40376.1, ECO:0000313|Proteomes:UP000003633};
RN [1] {ECO:0000313|EMBL:EJB40376.1, ECO:0000313|Proteomes:UP000003633}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp A-4 {ECO:0000313|EMBL:EJB40376.1,
RC ECO:0000313|Proteomes:UP000003633};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB40376.1}.
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DR EMBL; AKOA01000007; EJB40376.1; -; Genomic_DNA.
DR RefSeq; WP_000208605.1; NZ_AKOA01000007.1.
DR AlphaFoldDB; I9R1I3; -.
DR PATRIC; fig|992032.3.peg.1259; -.
DR Proteomes; UP000003633; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF1; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 66..308
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 597 AA; 69537 MW; 90186A3745BE29C3 CRC64;
MTTKLSCKGL SRSIQRFHID DIEKSIVKYT IETINPNHTD LSLFASNHNE DIVNILRDNK
TPICFDVFNA LFENLLDQER KTKFGMIFTP KYIADFICNE TFAKFEDLNN IKVIDPCCGC
GIFLISAIEQ IKSKTKKSIK QIIKNQIFGL DIDKDNVKKV ILLLKIMGLV YNENIEDCDI
NIRHCDSLIT DWKLAFDIDF DCIIGNPPYI NPHSLSKKQT AFLKQNFQTT SSGVFNIFYA
FIELGMKFIK PNGFLSYIVP NNFFTISAAK PLRDFIEPYL CELIDFKDNM VFKPTRTYST
IITLSLNDNK CIKYADIQKT NQVATYLDNI AYKMLDKKSV FGHKWRFLDF SVESNIKKIE
NQFFVLKPFI NTGIATLRDE VYCVDFDGKF FFKNVNGKKY IIDSDLIKPI YKIPKFKNSK
QSGYFIFPYT IKNNIATIID ERTMQREFSN TYEYLLARKN ELDLRDRGRA NPVSWYAYGR
TQGLNKSGKK LLFSTFGAKP NFIFIDNKTA LFCNGYAIVE NDSIELEILQ KVLNSCIVQY
YIQHTSYQID GGYFCYQKKY IEKFGIPYFD FKEKEFLLKA SPKEIDTFLI DKYEMIL
//