ID I9TEY8_HELPX Unreviewed; 275 AA.
AC I9TEY8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EJB67069.1};
DE EC=5.4.99.5 {ECO:0000313|EMBL:EJB67069.1};
GN Name=tyrA {ECO:0000313|EMBL:EJB67069.1};
GN ORFNames=HPHPH45_1322 {ECO:0000313|EMBL:EJB67069.1};
OS Helicobacter pylori Hp H-45.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992050 {ECO:0000313|EMBL:EJB67069.1, ECO:0000313|Proteomes:UP000003895};
RN [1] {ECO:0000313|EMBL:EJB67069.1, ECO:0000313|Proteomes:UP000003895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp H-45 {ECO:0000313|EMBL:EJB67069.1,
RC ECO:0000313|Proteomes:UP000003895};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB67069.1}.
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DR EMBL; AKOQ01000013; EJB67069.1; -; Genomic_DNA.
DR RefSeq; WP_000643509.1; NZ_AKOQ01000013.1.
DR AlphaFoldDB; I9TEY8; -.
DR PATRIC; fig|992050.3.peg.1293; -.
DR Proteomes; UP000003895; Unassembled WGS sequence.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:EJB67069.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 1..275
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 275 AA; 30405 MW; 896A05E6C29EBC5D CRC64;
MKAGIIGLGL MGGSLGLALQ EWGRFKSVIG YDHNALHAKL ALTLGLVDEC VEFEKILECD
VIFLAIPVEG IIGCLKKMTS IKKSTTIIDL GGAKAQIIHN IPKSIRQNFI AAHPMCGTEF
YGPKASVKGL YENALVILCD LEDSGTKQVE LAKEIFLGVK ARLIKMKSSE HDTHVAYISH
LPHVLSYALA NSVLKQNDPE MILSLAGGGF RDMSRLSKSS PLMWKDIFKQ NRDNVLEAIK
KCEKEIAQAK AWIENNDYES LAEWMAQANK LQEFM
//