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Database: UniProt
Entry: I9UFT2_HELPX
LinkDB: I9UFT2_HELPX
Original site: I9UFT2_HELPX 
ID   I9UFT2_HELPX            Unreviewed;       309 AA.
AC   I9UFT2;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=HPHPH3_0664 {ECO:0000313|EMBL:EJB80731.1};
OS   Helicobacter pylori Hp H-3.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=992059 {ECO:0000313|EMBL:EJB80731.1, ECO:0000313|Proteomes:UP000004029};
RN   [1] {ECO:0000313|EMBL:EJB80731.1, ECO:0000313|Proteomes:UP000004029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hp H-3 {ECO:0000313|EMBL:EJB80731.1,
RC   ECO:0000313|Proteomes:UP000004029};
RX   PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA   Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA   Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA   Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT   "Genome sequences of 65 Helicobacter pylori strains isolated from
RT   asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT   disease, or gastritis.";
RL   Pathog. Dis. 68:39-43(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJB80731.1}.
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DR   EMBL; AKOX01000005; EJB80731.1; -; Genomic_DNA.
DR   RefSeq; WP_000289438.1; NZ_AKOX01000005.1.
DR   AlphaFoldDB; I9UFT2; -.
DR   PATRIC; fig|992059.3.peg.635; -.
DR   Proteomes; UP000004029; Unassembled WGS sequence.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR012263; M_m6A_EcoRV.
DR   InterPro; IPR012327; MeTrfase_D12.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR30481; DNA ADENINE METHYLASE; 1.
DR   Pfam; PF02086; MethyltransfD12; 1.
DR   PIRSF; PIRSF000398; M_m6A_EcoRV; 1.
DR   PRINTS; PR00505; D12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:EJB80731.1};
KW   Transferase {ECO:0000313|EMBL:EJB80731.1}.
SQ   SEQUENCE   309 AA;  35939 MW;  AE001BCE9303958D CRC64;
     MYVNLFNQNA SKKDIFLHNL RSNNGRYKRY AKAPLRYGGG KSLAVGLIVE YIPNGVRRVI
     SPFIGGGSVE IACATELGLE VLGFDIFDIL VNFYQALLKD KQALYDNLFS LEPNQETYNT
     IKQELKAHYK KECVLDPLIL ARDYYFNFNL SYGPGFLGWM SKIYTDKQRY LNALLKIKDF
     NAPSLKVECS SFEEVLLAYP NDFFYLDPPY VLENSKMFKG IYPMRNFPIH HNGFKHEVLA
     HMLRRHKGPF ILSYNDCELV RNAYKDFKIL EPSWQYTMGQ GETRMGKNRL ERGDNNHVKQ
     PHELLIIKE
//
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