ID I9VT69_BACFG Unreviewed; 670 AA.
AC I9VT69;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=HMPREF1080_01660 {ECO:0000313|EMBL:EIY99058.1};
OS Bacteroides fragilis CL05T12C13.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=997881 {ECO:0000313|EMBL:EIY99058.1, ECO:0000313|Proteomes:UP000003917};
RN [1] {ECO:0000313|EMBL:EIY99058.1, ECO:0000313|Proteomes:UP000003917}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL05T12C13 {ECO:0000313|EMBL:EIY99058.1,
RC ECO:0000313|Proteomes:UP000003917};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides fragilis CL05T12C13.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIY99058.1}.
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DR EMBL; AGXP01000019; EIY99058.1; -; Genomic_DNA.
DR RefSeq; WP_005800569.1; NZ_JH724193.1.
DR AlphaFoldDB; I9VT69; -.
DR PATRIC; fig|997881.3.peg.1728; -.
DR HOGENOM; CLU_013588_0_0_10; -.
DR Proteomes; UP000003917; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 26..143
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 146..249
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 285
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 670 AA; 77344 MW; 6F505144A7FD6720 CRC64;
MRNKQIFLIS FIIYLCTISS VRAGEYHLLP EPQKFTPLGS SFVLGRTKLS TPVLRQEWEA
FVVDRGGVID DKARASIEVK LVPSLEEVPL NADEAYRLVV NNGKVTVEAV TEHGVYWAMQ
TLAQLQDVQK KKATFNGCSI VDWPAFRIRG FMQDVGRTYM SIEELKREIA VLSRFKINVF
HWHLTENQSW RLQSKIFPML NDSVNTTRMP GKYYTLEEAK DLVAFCKAHN ILLIPEFDMP
GHSEAFVRTF RHDMQSPEGM KILKLLVDEV CETFDVPYLH IGTDEVRFTN PKFVPEMVEY
VRAKGKKVIS WNPGWHYKPG EIDMTHLWSY RGKAQKGIPA IDSKFHYLNH FDTFGDIIAL
YNSRIYNVEQ GSDDIAGTIL AIWNDRYVAN ERNIILENNF YPNMLAIAER AWKGGGTEYF
DKNGTILPSE DSPEFKEFAD FENRMLWHKE HTFKGYPFAY VKQTNVKWNI TDAFPNGGDL
NKVFPPEQEL KDSYLYEGKE YGVHPAIGAG IYLRHVWGKM VPTFYKDPQE NHTAYAYTWV
YSPKDQEVGL WAEYQNYGRS EMDLAPLQGK WDYKGSRIWI NNEEIQPPVW TATHRTKSNE
IALGNENCVA RPPIAVHLNK GWNKVFLKLP VGKFNMPEVR LVKWMFTTVF VTPDGENAVD
GLIYSPDKTK
//
