ID I9WVW7_HELPX Unreviewed; 685 AA.
AC I9WVW7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN Name=fliD {ECO:0000313|EMBL:EJC07760.1};
GN ORFNames=HPHPP15_1095 {ECO:0000313|EMBL:EJC07760.1};
OS Helicobacter pylori Hp P-15.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992080 {ECO:0000313|EMBL:EJC07760.1, ECO:0000313|Proteomes:UP000005838};
RN [1] {ECO:0000313|EMBL:EJC07760.1, ECO:0000313|Proteomes:UP000005838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-15 {ECO:0000313|EMBL:EJC07760.1,
RC ECO:0000313|Proteomes:UP000005838};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC07760.1}.
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DR EMBL; AKPP01000003; EJC07760.1; -; Genomic_DNA.
DR RefSeq; WP_001900351.1; NZ_AKPP01000003.1.
DR AlphaFoldDB; I9WVW7; -.
DR PATRIC; fig|992080.3.peg.1073; -.
DR Proteomes; UP000005838; Unassembled WGS sequence.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07196; Flagellin_IN; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Cell projection {ECO:0000313|EMBL:EJC07760.1};
KW Cilium {ECO:0000313|EMBL:EJC07760.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Flagellum {ECO:0000313|EMBL:EJC07760.1};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 19..108
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 433..668
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
SQ SEQUENCE 685 AA; 74247 MW; B79B0E02D6BEF7AD CRC64;
MAIGSLSSLG LGSKVLNYDV IDKLKDADEK ALIAPLDKKM EQNVEKQKAL VEIKTLLSSL
KGPVKTLSDY STYISRKSNV TGDALSASVG AGVPIQDIKV DVQNLAQGDI NELGAKFSSR
DDIFSQVDTT LKFYTQNKDY AVDIKAGMTL GDVAQSITDA TNGEVMGIVM KTGGNDPYQL
MVNTKNTGED NRIYFGSHLQ STLTNKNALS LGVDGSGKSE VSLNLKGADG NMHEVPIMLE
LPESASIKQK NTAIQKAIEQ ALENDPNFKD LIANGDISID TLHGGESLII NDRRGGNIEI
KGSKAKELGF LQTTTQESDL LKSSRTIKEG KLEGVVSLNG QKLDLKALTK ESNTSEENTD
AIIQAINSKE GLSAFKNAEG KLVINSKTGM LTIKGEDALG KASLKDLGLS AGMVQSYEAS
QDTLFMSKNL QKASDSEFTY NGVSITRPTN EVNDVINGVN ITLEQTTEPN KPAIISVSRD
NQAIIDSLTE FVKAYNELIP KLDEDTRYDA DTKIAGIFNG VGDIRAIRSS LNNVFSYSVH
TDNGVESLMK YGLSLDDKGV MSLDEAKLSS ALNSNPKATQ DFFYGSDSKD MGGREIHQEG
IFSKFNQVIA NLIDGGNAKL KIYEDSLDRD AKSLTKDKEN AQELLKTRYN IMAERFAAYD
SQISKANQKF NSVQMMIDQA AAKKN
//
