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Database: UniProt
Entry: IL10_CHICK
LinkDB: IL10_CHICK
Original site: IL10_CHICK 
ID   IL10_CHICK              Reviewed;         175 AA.
AC   Q6A2H4; Q6A2H5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   09-JUL-2014, entry version 79.
DE   RecName: Full=Interleukin-10;
DE            Short=IL-10;
DE   Flags: Precursor;
GN   Name=IL10;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Cecum;
RX   PubMed=15294985; DOI=10.4049/jimmunol.173.4.2675;
RA   Rothwell L., Young J.R., Zoorob R., Whittaker C.A., Hesketh P.,
RA   Archer A., Smith A.L., Kaiser P.;
RT   "Cloning and characterization of chicken IL-10 and its role in the
RT   immune response to Eimeria maxima.";
RL   J. Immunol. 173:2675-2682(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX   PubMed=15932414; DOI=10.1111/j.1365-2052.2005.01264.x;
RA   Yilmaz A., Shen S., Adelson D.L., Xavier S., Zhu J.;
RT   "Annotation of the chicken IL10 gene cluster and effects of
RT   lipopolysaccharide stimulation on IL10 gene expression.";
RL   Anim. Genet. 36:263-265(2005).
RN   [3]
RP   INDUCTION.
RX   PubMed=16996141; DOI=10.1016/j.vetimm.2006.07.007;
RA   Hong Y.H., Lillehoj H.S., Lee S.H., Dalloul R.A., Lillehoj E.P.;
RT   "Analysis of chicken cytokine and chemokine gene expression following
RT   Eimeria acervulina and Eimeria tenella infections.";
RL   Vet. Immunol. Immunopathol. 114:209-223(2006).
RN   [4]
RP   INDUCTION.
RX   PubMed=17045659; DOI=10.1016/j.vetimm.2006.08.006;
RA   Hong Y.H., Lillehoj H.S., Lillehoj E.P., Lee S.H.;
RT   "Changes in immune-related gene expression and intestinal lymphocyte
RT   subpopulations following Eimeria maxima infection of chickens.";
RL   Vet. Immunol. Immunopathol. 114:259-272(2006).
RN   [5]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=17575181;
RA   Abdul-Careem M.F., Hunter D.B., Lambourne M.D., Barta J., Sharif S.;
RT   "Ontogeny of cytokine gene expression in the chicken spleen.";
RL   Poult. Sci. 86:1351-1355(2007).
CC   -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC       including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC       activated macrophages and by helper T-cells.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in bursa of Fabricius
CC       and cecal tonsils with low levels in thymus, liver and lung.
CC   -!- DEVELOPMENTAL STAGE: Expression is detected as early as embryonic
CC       day 12. Higher expression in spleen of post-hatch chickens than
CC       embryos. Gradual increase in expression in the spleen which peaks
CC       by day 7 post-hatch.
CC   -!- INDUCTION: By lipopolysaccharide (LPS) in white blood cells, liver
CC       and spleen 3 hours after treatment. Decreases to basal levels 8
CC       hours after treatment. By primary infection with E.acervulina and
CC       E.tenella.
CC   -!- MISCELLANEOUS: Chickens susceptible to E.maxima infection show
CC       higher constitutive and post-infection levels in spleen and higher
CC       post-infection levels in small intestine than infection-resistant
CC       animals.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
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DR   EMBL; AJ621614; CAF21727.1; -; Genomic_DNA.
DR   EMBL; AJ621254; CAF18432.1; -; mRNA.
DR   EMBL; AY647438; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001004414.2; NM_001004414.2.
DR   UniGene; Gga.46641; -.
DR   ProteinModelPortal; Q6A2H4; -.
DR   PaxDb; Q6A2H4; -.
DR   PRIDE; Q6A2H4; -.
DR   Ensembl; ENSGALT00000001312; ENSGALP00000001310; ENSGALG00000000892.
DR   GeneID; 428264; -.
DR   KEGG; gga:428264; -.
DR   CTD; 3586; -.
DR   eggNOG; NOG43085; -.
DR   GeneTree; ENSGT00510000048535; -.
DR   HOGENOM; HOG000072692; -.
DR   HOVERGEN; HBG004110; -.
DR   InParanoid; Q6A2H4; -.
DR   KO; K05443; -.
DR   PhylomeDB; Q6A2H4; -.
DR   NextBio; 20829305; -.
DR   PRO; PR:Q6A2H4; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0042832; P:defense response to protozoan; IDA:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
DR   GO; GO:0002875; P:negative regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
DR   GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl.
DR   GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
DR   GO; GO:0045077; P:negative regulation of interferon-gamma biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR   GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR   GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IEA:Ensembl.
DR   GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IC:UniProtKB.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
DR   GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0032800; P:receptor biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000098; IL-10.
DR   InterPro; IPR020443; IL-10/19/20/24/26_fam.
DR   PANTHER; PTHR11585; PTHR11585; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01294; INTRLEUKIN10.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    175       Interleukin-10.
FT                                /FTId=PRO_0000296319.
FT   DISULFID     26    123       By similarity.
FT   DISULFID     77    129       By similarity.
FT   CONFLICT    120    120       M -> I (in Ref. 1; CAF21727).
SQ   SEQUENCE   175 AA;  20514 MW;  B0966EBEAFDFB050 CRC64;
     MQTCCQALLL LLAACTLPAH CLEPTCLHFS ELLPARLREL RVKFEEIKDY FQSRDDELNI
     QLLSSELLDE FKGTFGCQSV SEMLRFYTDE VLPRAMQTST SHQQSMGDLG NMLLGLKATM
     RRCHRFFTCE KRSKAIKQIK ETFEKMDENG IYKAMGEFDI FINYIEEYLL MRRRK
//
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