ID IL10_CHICK Reviewed; 175 AA.
AC Q6A2H4; Q6A2H5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-APR-2013, entry version 69.
DE RecName: Full=Interleukin-10;
DE Short=IL-10;
DE Flags: Precursor;
GN Name=IL10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Cecum;
RX PubMed=15294985;
RA Rothwell L., Young J.R., Zoorob R., Whittaker C.A., Hesketh P.,
RA Archer A., Smith A.L., Kaiser P.;
RT "Cloning and characterization of chicken IL-10 and its role in the
RT immune response to Eimeria maxima.";
RL J. Immunol. 173:2675-2682(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX PubMed=15932414; DOI=10.1111/j.1365-2052.2005.01264.x;
RA Yilmaz A., Shen S., Adelson D.L., Xavier S., Zhu J.;
RT "Annotation of the chicken IL10 gene cluster and effects of
RT lipopolysaccharide stimulation on IL10 gene expression.";
RL Anim. Genet. 36:263-265(2005).
RN [3]
RP INDUCTION.
RX PubMed=16996141; DOI=10.1016/j.vetimm.2006.07.007;
RA Hong Y.H., Lillehoj H.S., Lee S.H., Dalloul R.A., Lillehoj E.P.;
RT "Analysis of chicken cytokine and chemokine gene expression following
RT Eimeria acervulina and Eimeria tenella infections.";
RL Vet. Immunol. Immunopathol. 114:209-223(2006).
RN [4]
RP INDUCTION.
RX PubMed=17045659; DOI=10.1016/j.vetimm.2006.08.006;
RA Hong Y.H., Lillehoj H.S., Lillehoj E.P., Lee S.H.;
RT "Changes in immune-related gene expression and intestinal lymphocyte
RT subpopulations following Eimeria maxima infection of chickens.";
RL Vet. Immunol. Immunopathol. 114:259-272(2006).
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=17575181;
RA Abdul-Careem M.F., Hunter D.B., Lambourne M.D., Barta J., Sharif S.;
RT "Ontogeny of cytokine gene expression in the chicken spleen.";
RL Poult. Sci. 86:1351-1355(2007).
CC -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC activated macrophages and by helper T-cells.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC -!- TISSUE SPECIFICITY: Expressed predominantly in bursa of Fabricius
CC and cecal tonsils with low levels in thymus, liver and lung.
CC -!- DEVELOPMENTAL STAGE: Expression is detected as early as embryonic
CC day 12. Higher expression in spleen of post-hatch chickens than
CC embryos. Gradual increase in expression in the spleen which peaks
CC by day 7 post-hatch.
CC -!- INDUCTION: By lipopolysaccharide (LPS) in white blood cells, liver
CC and spleen 3 hours after treatment. Decreases to basal levels 8
CC hours after treatment. By primary infection with E.acervulina and
CC E.tenella.
CC -!- MISCELLANEOUS: Chickens susceptible to E.maxima infection show
CC higher constitutive and post-infection levels in spleen and higher
CC post-infection levels in small intestine than infection-resistant
CC animals.
CC -!- SIMILARITY: Belongs to the IL-10 family.
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DR EMBL; AJ621614; CAF21727.1; -; Genomic_DNA.
DR EMBL; AJ621254; CAF18432.1; -; mRNA.
DR EMBL; AY647438; -; NOT_ANNOTATED_CDS; mRNA.
DR IPI; IPI00586890; -.
DR RefSeq; NP_001004414.2; NM_001004414.2.
DR UniGene; Gga.46641; -.
DR HSSP; P22301; 1LK3.
DR ProteinModelPortal; Q6A2H4; -.
DR PaxDb; Q6A2H4; -.
DR PRIDE; Q6A2H4; -.
DR GeneID; 428264; -.
DR KEGG; gga:428264; -.
DR CTD; 3586; -.
DR eggNOG; NOG43085; -.
DR HOGENOM; HOG000072692; -.
DR HOVERGEN; HBG004110; -.
DR InParanoid; Q6A2H4; -.
DR KO; K05443; -.
DR OrthoDB; EOG4F1X4G; -.
DR NextBio; 20829305; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0042832; P:defense response to protozoan; IDA:UniProtKB.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045077; P:negative regulation of interferon-gamma biosynthetic process; IDA:UniProtKB.
DR GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:UniProtKB.
DR GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IC:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR020443; Interleukin-10/19/20/24.
DR InterPro; IPR000098; Interleukin_10.
DR PANTHER; PTHR11585; PTHR11585; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01294; INTRLEUKIN10.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytokine; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1 21 Potential.
FT CHAIN 22 175 Interleukin-10.
FT /FTId=PRO_0000296319.
FT DISULFID 26 123 By similarity.
FT DISULFID 77 129 By similarity.
FT CONFLICT 120 120 M -> I (in Ref. 1; CAF21727).
SQ SEQUENCE 175 AA; 20514 MW; B0966EBEAFDFB050 CRC64;
MQTCCQALLL LLAACTLPAH CLEPTCLHFS ELLPARLREL RVKFEEIKDY FQSRDDELNI
QLLSSELLDE FKGTFGCQSV SEMLRFYTDE VLPRAMQTST SHQQSMGDLG NMLLGLKATM
RRCHRFFTCE KRSKAIKQIK ETFEKMDENG IYKAMGEFDI FINYIEEYLL MRRRK
//
