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Database: UniProt
Entry: IL13_HUMAN
LinkDB: IL13_HUMAN
Original site: IL13_HUMAN 
ID   IL13_HUMAN              Reviewed;         146 AA.
AC   P35225; O43644; Q4VB52; Q9UDC7;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   09-JUL-2014, entry version 155.
DE   RecName: Full=Interleukin-13;
DE            Short=IL-13;
DE   Flags: Precursor;
GN   Name=IL13; Synonyms=NC30;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8096327; DOI=10.1038/362248a0;
RA   Minty A.J., Chalon P., Derocq J.-M., Dumont X., Guillemot J.-C.,
RA   Kaghad M., Labit C., Leplatois P., Liauzun P., Miloux B., Minty C.,
RA   Casellas P., Loison G., Lupker J., Shire D., Ferrara P., Caput D.;
RT   "Interleukin-13 is a new human lymphokine regulating inflammatory and
RT   immune responses.";
RL   Nature 362:248-250(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8097324; DOI=10.1073/pnas.90.8.3735;
RA   McKenzie A.N., Culpepper J.A., Waal Malefyt R., Briere F.,
RA   Punnonen J., Aversa G., Sato A., Dang W., Cocks B.G., Menon S.,
RA   de Vries J.E., Banchereau J., Zurawski G.R.;
RT   "Interleukin 13, a T-cell-derived cytokine that regulates human
RT   monocyte and B-cell function.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=7721105; DOI=10.1016/0378-1119(94)00720-D;
RA   Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.;
RT   "Tandem arrangement of human genes for interleukin-4 and interleukin-
RT   13: resemblance in their organization.";
RL   Gene 155:277-281(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8605348;
RA   Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D.,
RA   McGurn M., Gibson C., Lewis D.B.;
RT   "Coexpression of the interleukin-13 and interleukin-4 genes correlates
RT   with their physical linkage in the cytokine gene cluster on human
RT   chromosome 5q23-31.";
RL   Blood 87:3316-3326(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-144.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-144.
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-144.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 14-146.
RA   Jang J.S., Kim B.E.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 15-63.
RC   TISSUE=Peripheral blood lymphocyte;
RX   PubMed=1408833; DOI=10.1093/nar/20.19.5173;
RA   Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.;
RT   "The selective isolation of novel cDNAs encoded by the regions
RT   surrounding the human interleukin 4 and 5 genes.";
RL   Nucleic Acids Res. 20:5173-5179(1992).
RN   [10]
RP   STRUCTURE BY NMR OF 35-146, AND DISULFIDE BONDS.
RX   PubMed=11419948; DOI=10.1006/jmbi.2001.4764;
RA   Moy F.J., Diblasio E., Wilhelm J., Powers R.;
RT   "Solution structure of human IL-13 and implication for receptor
RT   binding.";
RL   J. Mol. Biol. 310:219-230(2001).
RN   [11]
RP   X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 15-146 IN COMPLEX WITH
RP   IL13RA2, AND DISULFIDE BONDS.
RX   PubMed=20223216; DOI=10.1016/j.str.2010.01.003;
RA   Lupardus P.J., Birnbaum M.E., Garcia K.C.;
RT   "Molecular basis for shared cytokine recognition revealed in the
RT   structure of an unusually high affinity complex between IL-13 and IL-
RT   13Ralpha2.";
RL   Structure 18:332-342(2010).
RN   [12]
RP   VARIANT GLN-144.
RX   PubMed=10699178; DOI=10.1093/hmg/9.4.549;
RA   Heinzmann A., Mao X.-Q., Akaiwa M., Kreomer R.T., Gao P.-S.,
RA   Ohshima K., Umeshita R., Abe Y., Braun S., Yamashita T., Roberts M.H.,
RA   Sugimoto R., Arima K., Arinobu Y., Yu B., Kruse S., Enomoto T.,
RA   Dake Y., Kawai M., Shimazu S., Sasaki S., Adra C.N., Kitaichi M.,
RA   Inoue H., Yamauchi K., Tomichi N., Kurimoto F., Hamasaki N.,
RA   Hopkin J.M., Izuhara K., Shirakawa T., Deichmann K.A.;
RT   "Genetic variants of IL-13 signalling and human asthma and atopy.";
RL   Hum. Mol. Genet. 9:549-559(2000).
RN   [13]
RP   VARIANT GLN-144.
RX   PubMed=11588017; DOI=10.1165/ajrcmb.25.3.4483;
RA   Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J.,
RA   Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.;
RT   "Identification and association of polymorphisms in the interleukin-13
RT   gene with asthma and atopy in a Dutch population.";
RL   Am. J. Respir. Cell Mol. Biol. 25:377-384(2001).
RN   [14]
RP   VARIANT GLN-144.
RX   PubMed=12928861; DOI=10.1007/s00439-003-1001-x;
RA   Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W.,
RA   Yu L.-S.;
RT   "A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese
RT   atopy patients with allergic rhinitis.";
RL   Hum. Genet. 113:387-390(2003).
CC   -!- FUNCTION: Cytokine. Inhibits inflammatory cytokine production.
CC       Synergizes with IL2 in regulating interferon-gamma synthesis. May
CC       be critical in regulating inflammatory and immune responses.
CC   -!- SUBUNIT: Interacts with IL13RA2.
CC   -!- INTERACTION:
CC       P78552:IL13RA1; NbExp=4; IntAct=EBI-1647828, EBI-1391535;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DISEASE: Allergic rhinitis (ALRH) [MIM:607154]: A common disease
CC       with complex inheritance characterized by mucosal inflammation
CC       caused by allergen exposure. Note=Disease susceptibility is
CC       associated with variations affecting the gene represented in this
CC       entry.
CC   -!- SIMILARITY: Belongs to the IL-4/IL-13 family.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-13 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_13";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il13/";
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DR   EMBL; X69079; CAA48823.1; -; mRNA.
DR   EMBL; X69079; CAA48824.1; ALT_INIT; mRNA.
DR   EMBL; L06801; AAA36107.1; ALT_INIT; mRNA.
DR   EMBL; U10307; AAA83738.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U31120; AAB01681.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF377331; AAK53823.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC004039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC096139; AAH96139.1; -; mRNA.
DR   EMBL; AF043334; AAC03535.1; ALT_INIT; mRNA.
DR   CCDS; CCDS4157.1; -.
DR   PIR; I38060; A47481.
DR   RefSeq; NP_002179.2; NM_002188.2.
DR   UniGene; Hs.845; -.
DR   PDB; 1GA3; NMR; -; A=35-146.
DR   PDB; 1IJZ; NMR; -; A=35-146.
DR   PDB; 1IK0; NMR; -; A=35-146.
DR   PDB; 1J9U; Model; -; A=38-146.
DR   PDB; 3BPO; X-ray; 3.00 A; A=34-146.
DR   PDB; 3G6D; X-ray; 3.20 A; A=35-146.
DR   PDB; 3ITR; Model; -; A=38-146.
DR   PDB; 3ITS; Model; -; A=38-146.
DR   PDB; 3L5W; X-ray; 2.00 A; I/J=35-146.
DR   PDB; 3L5X; X-ray; 1.90 A; A=35-146.
DR   PDB; 3LB6; X-ray; 3.05 A; A/B=15-146.
DR   PDB; 4I77; X-ray; 1.90 A; Z=35-146.
DR   PDB; 4PS4; X-ray; 2.80 A; A=35-146.
DR   PDBsum; 1GA3; -.
DR   PDBsum; 1IJZ; -.
DR   PDBsum; 1IK0; -.
DR   PDBsum; 1J9U; -.
DR   PDBsum; 3BPO; -.
DR   PDBsum; 3G6D; -.
DR   PDBsum; 3ITR; -.
DR   PDBsum; 3ITS; -.
DR   PDBsum; 3L5W; -.
DR   PDBsum; 3L5X; -.
DR   PDBsum; 3LB6; -.
DR   PDBsum; 4I77; -.
DR   PDBsum; 4PS4; -.
DR   ProteinModelPortal; P35225; -.
DR   SMR; P35225; 38-146.
DR   BioGrid; 109810; 1.
DR   DIP; DIP-3224N; -.
DR   IntAct; P35225; 1.
DR   STRING; 9606.ENSP00000304915; -.
DR   DMDM; 239938644; -.
DR   PRIDE; P35225; -.
DR   DNASU; 3596; -.
DR   Ensembl; ENST00000304506; ENSP00000304915; ENSG00000169194.
DR   GeneID; 3596; -.
DR   KEGG; hsa:3596; -.
DR   CTD; 3596; -.
DR   GeneCards; GC05P131991; -.
DR   H-InvDB; HIX0031957; -.
DR   HGNC; HGNC:5973; IL13.
DR   HPA; HPA042421; -.
DR   MIM; 147683; gene.
DR   MIM; 607154; phenotype.
DR   neXtProt; NX_P35225; -.
DR   PharmGKB; PA199; -.
DR   eggNOG; NOG42350; -.
DR   HOGENOM; HOG000113028; -.
DR   HOVERGEN; HBG006140; -.
DR   InParanoid; P35225; -.
DR   KO; K05435; -.
DR   OrthoDB; EOG78SQMB; -.
DR   PhylomeDB; P35225; -.
DR   TreeFam; TF336383; -.
DR   SignaLink; P35225; -.
DR   ChiTaRS; IL13; human.
DR   EvolutionaryTrace; P35225; -.
DR   GeneWiki; Interleukin_13; -.
DR   GenomeRNAi; 3596; -.
DR   NextBio; 14053; -.
DR   PRO; PR:P35225; -.
DR   ArrayExpress; P35225; -.
DR   Bgee; P35225; -.
DR   CleanEx; HS_IL13; -.
DR   Genevestigator; P35225; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IDA:BHF-UCL.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0007267; P:cell-cell signaling; IC:UniProtKB.
DR   GO; GO:0006928; P:cellular component movement; TAS:ProtInc.
DR   GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR   GO; GO:1901247; P:negative regulation of lung ciliated cell differentiation; NAS:BHF-UCL.
DR   GO; GO:0071635; P:negative regulation of transforming growth factor beta production; IEA:Ensembl.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR   GO; GO:0032723; P:positive regulation of connective tissue growth factor production; IEA:Ensembl.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR   GO; GO:1901251; P:positive regulation of lung goblet cell differentiation; NAS:BHF-UCL.
DR   GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
DR   GO; GO:2000231; P:positive regulation of pancreatic stellate cell proliferation; IEA:Ensembl.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0042526; P:positive regulation of tyrosine phosphorylation of Stat6 protein; IEA:Ensembl.
DR   GO; GO:0010155; P:regulation of proton transport; IEA:Ensembl.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020470; IL-13.
DR   InterPro; IPR001325; IL-4/IL-13.
DR   InterPro; IPR018096; IL-4/IL-13_CS.
DR   PANTHER; PTHR11322; PTHR11322; 1.
DR   Pfam; PF03487; IL13; 1.
DR   PRINTS; PR01929; INTRLEUKIN13.
DR   SMART; SM00190; IL4_13; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytokine; Disulfide bond;
KW   Glycoprotein; Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     24       Potential.
FT   CHAIN        25    146       Interleukin-13.
FT                                /FTId=PRO_0000015547.
FT   CARBOHYD     52     52       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     63     63       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     71     71       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     86     86       N-linked (GlcNAc...) (Potential).
FT   DISULFID     62     90
FT   DISULFID     78    104
FT   VARIANT     144    144       R -> Q (associated with increased risk
FT                                for asthma development; at homozygosity
FT                                associated with higher levels of serum
FT                                total IgE in some allergic rhinitis
FT                                patients; dbSNP:rs20541).
FT                                /FTId=VAR_010037.
FT   CONFLICT      1      1       M -> R (in Ref. 2; CAA48824).
FT   CONFLICT     26     26       T -> A (in Ref. 9; no nucleotide entry).
FT   CONFLICT     32     32       A -> D (in Ref. 9; no nucleotide entry).
FT   CONFLICT     51     51       V -> S (in Ref. 9; no nucleotide entry).
FT   CONFLICT     56     56       N -> T (in Ref. 9; no nucleotide entry).
FT   CONFLICT     59     59       A -> R (in Ref. 3; AAA83738).
FT   CONFLICT    101    101       S -> G (in Ref. 8; AAC03535).
FT   CONFLICT    112    112       Missing (in Ref. 3; AAA83738).
FT   HELIX        41     54
FT   TURN         61     64
FT   STRAND       66     68
FT   TURN         74     76
FT   HELIX        77     84
FT   HELIX        91     93
FT   HELIX        94    103
FT   STRAND      104    106
FT   STRAND      122    124
FT   HELIX       125    142
SQ   SEQUENCE   146 AA;  15816 MW;  BE2D46CCF913D129 CRC64;
     MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL VNITQNQKAP
     LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML SGFCPHKVSA GQFSSLHVRD
     TKIEVAQFVK DLLLHLKKLF REGRFN
//
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