ID IRX1_HUMAN Reviewed; 480 AA.
AC P78414; Q7Z2F8; Q8N312;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 3.
DT 27-MAR-2024, entry version 172.
DE RecName: Full=Iroquois-class homeodomain protein IRX-1;
DE AltName: Full=Homeodomain protein IRXA1;
DE AltName: Full=Iroquois homeobox protein 1;
GN Name=IRX1; Synonyms=IRXA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Hansen L., Wu Q., Tommerup N.;
RT "Characterization of the human homeobox two-cluster Iroquois gene family.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-480.
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 84-176.
RA Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.;
RT "IRX: a new family of human homeobox genes from the breast.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR EMBL; AY335938; AAQ16544.1; -; mRNA.
DR EMBL; AY335947; AAQ16553.1; -; Genomic_DNA.
DR EMBL; BC029160; AAH29160.1; -; mRNA.
DR EMBL; U90307; AAB50005.1; -; mRNA.
DR CCDS; CCDS34132.1; -.
DR RefSeq; NP_077313.3; NM_024337.3.
DR AlphaFoldDB; P78414; -.
DR SMR; P78414; -.
DR BioGRID; 122604; 9.
DR STRING; 9606.ENSP00000305244; -.
DR iPTMnet; P78414; -.
DR PhosphoSitePlus; P78414; -.
DR BioMuta; IRX1; -.
DR DMDM; 47117873; -.
DR EPD; P78414; -.
DR jPOST; P78414; -.
DR MassIVE; P78414; -.
DR MaxQB; P78414; -.
DR PaxDb; 9606-ENSP00000305244; -.
DR PeptideAtlas; P78414; -.
DR ProteomicsDB; 57619; -.
DR Antibodypedia; 9131; 214 antibodies from 31 providers.
DR DNASU; 79192; -.
DR Ensembl; ENST00000302006.4; ENSP00000305244.3; ENSG00000170549.4.
DR GeneID; 79192; -.
DR KEGG; hsa:79192; -.
DR MANE-Select; ENST00000302006.4; ENSP00000305244.3; NM_024337.4; NP_077313.3.
DR UCSC; uc003jde.3; human.
DR AGR; HGNC:14358; -.
DR CTD; 79192; -.
DR DisGeNET; 79192; -.
DR GeneCards; IRX1; -.
DR HGNC; HGNC:14358; IRX1.
DR HPA; ENSG00000170549; Tissue enhanced (breast, kidney, salivary gland).
DR MIM; 606197; gene.
DR neXtProt; NX_P78414; -.
DR OpenTargets; ENSG00000170549; -.
DR PharmGKB; PA29924; -.
DR VEuPathDB; HostDB:ENSG00000170549; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000160429; -.
DR HOGENOM; CLU_042927_0_0_1; -.
DR InParanoid; P78414; -.
DR OMA; QVNHTST; -.
DR OrthoDB; 2915644at2759; -.
DR PhylomeDB; P78414; -.
DR TreeFam; TF319371; -.
DR PathwayCommons; P78414; -.
DR SignaLink; P78414; -.
DR SIGNOR; P78414; -.
DR BioGRID-ORCS; 79192; 14 hits in 1168 CRISPR screens.
DR GeneWiki; IRX1; -.
DR GenomeRNAi; 79192; -.
DR Pharos; P78414; Tbio.
DR PRO; PR:P78414; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P78414; Protein.
DR Bgee; ENSG00000170549; Expressed in parotid gland and 96 other cell types or tissues.
DR Genevisible; P78414; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0072272; P:proximal/distal pattern formation involved in metanephric nephron development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0072086; P:specification of loop of Henle identity; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF13; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..480
FT /note="Iroquois-class homeodomain protein IRX-1"
FT /id="PRO_0000049151"
FT DNA_BIND 125..188
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 190..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..418
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P81068"
FT CONFLICT 138
FT /note="S -> N (in Ref. 2; AAB50005)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 49621 MW; ABC3A7069593E0E1 CRC64;
MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV
LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY
GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN
ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ
SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG
AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS
HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP
GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA
//
