ID   IWS1_CRYNJ              Reviewed;         475 AA.
AC   P0CO38; Q55WI4; Q5KJR1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=CNC05650;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; AE017343; AAW42473.1; -; Genomic_DNA.
DR   RefSeq; XP_569780.1; XM_569780.1.
DR   AlphaFoldDB; P0CO38; -.
DR   SMR; P0CO38; -.
DR   STRING; 214684.P0CO38; -.
DR   PaxDb; 214684-P0CO38; -.
DR   EnsemblFungi; AAW42473; AAW42473; CNC05650.
DR   GeneID; 3256341; -.
DR   KEGG; cne:CNC05650; -.
DR   VEuPathDB; FungiDB:CNC05650; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_045275_2_2_1; -.
DR   InParanoid; P0CO38; -.
DR   OMA; AFDEYME; -.
DR   OrthoDB; 12240at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR   PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..475
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083357"
FT   DOMAIN          290..367
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..55
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  54385 MW;  28B5C2BA3DED8109 CRC64;
     MSSPALDTIH DQTGEQDLHQ EVQAQEHLPV EPTPEVQEEP ESDHQDDDEQ PEAQVLEQEQ
     EQVAEQERLQ DQEDQDQGAE LVSQQPTAEE QEETRDELYN EVFGNQGSEA SDLSDDEDVR
     MDEGEKYVPA TATSAAKIPK FKKSKRDDED EDEDEDEDED DGGERRRKKK KRAERRRQRQ
     EEEDEDEAPV LDEATQRRLA LEERIDAIGK KPKAIRRKKK GDDDVDIVDS YHDDICARLR
     DRMIAAADKD EAANRIKMPG TAKLAMLDEV MGVLRNTTLW QSIVDNGVLE AVKRWLEPLP
     DKSLPSVGIQ KAIFEVLPKM DLDTTTLKEC RLGPIVLFYT KTKRVTPAIN RQADALVQAW
     SRPIIKRPAN YRSRYIESQN EVEQSQGGGG TGGGYSQSQR GPGERKFKRF DVKKALEENA
     HRKGARLQIV QDVQYTVAPE PKTHHHAEEM QHVSRIQQDN KKFNRFARQV KTKKH
//