ID J0ASU1_HELPX Unreviewed; 788 AA.
AC J0ASU1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Putative cation-transporting ATPase, P-type {ECO:0000313|EMBL:EJB52868.1};
GN ORFNames=HPHPH24_0068 {ECO:0000313|EMBL:EJB52868.1};
OS Helicobacter pylori Hp H-24.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992039 {ECO:0000313|EMBL:EJB52868.1, ECO:0000313|Proteomes:UP000004761};
RN [1] {ECO:0000313|EMBL:EJB52868.1, ECO:0000313|Proteomes:UP000004761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp H-24 {ECO:0000313|EMBL:EJB52868.1,
RC ECO:0000313|Proteomes:UP000004761};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB52868.1}.
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DR EMBL; AKOG01000001; EJB52868.1; -; Genomic_DNA.
DR RefSeq; WP_000650235.1; NZ_AKOG01000001.1.
DR AlphaFoldDB; J0ASU1; -.
DR PATRIC; fig|992039.3.peg.68; -.
DR Proteomes; UP000004761; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR021993; ATPase-cat-bd.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF5; CATION-TRANSPORTING P-TYPE ATPASE-RELATED; 1.
DR Pfam; PF12156; ATPase-cat_bd; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 452..481
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 743..762
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 82..147
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 788 AA; 86931 MW; 9CABF4C299E0A595 CRC64;
MKCSHCQLEF KESELFKEVI NHKELHFCCT GCARVYMLLL DLNLESFYDK LNDSTLAPVT
PQDSMSALEL EQALEENNKG ELILNLLLEK THCNACLWLN QKVLERLKGV KKVSVNFTTH
HLQIVFDRSL NPKEIIQKIE SLGYGAKIYN VQNYTLKAQK EQRSYLLTLS VGFFATMNLM
FIAIAKYASY GSAGYGAAGY GSGMDKLMQR NLDLVSLFLS LLVLVVVGRF FIKGAFYGLK
NGVLGMDLSV SFGALSAFVY SLYAMLVSQE TYFEASSTIL TLVFGSKFLE LKARLFANEK
CLALESHEIH SVIVVENGKQ IEKHPKDVAI GSVVWVPSGA KIALDGVLLN NASVDASLIS
GEFKPLELGV NDPILGGYVN VGVPFSYQVS ATFQNSRLSG LLETLKKSFL EKPLIESSAN
QIADIFSKAV LFLAFVSFLL WQFGLGGNFE KALMVCISVL VISCPCAFAL ATPIALVIGV
FKNPLIVFKE ALFLETLAKV KKIFIDKTGT LTQKEVLLKE KIIYKEFDER LLKSLLKTRE
HLAHSAILKT LDSDEVDLEK IEFFAHGLKA NYQNETLLVG SLKFLKSMGV DLKVKESANI
MVGFTKNKTL CALFILEERL KANAKEVIQA LQNKGLELEI LSGDNESSVK ECAKKLGISK
YHAHLTPEDK AQIISSYQGV CAMVGDGNND ALALKQASVS LGFEKSALSK SACDILLLEE
DLSLLEKAFD NAQKVYQVVL QNIVLSLIYN AVLIPVAMLG YINPLTASLS MSASSLLVVL
NSLRLKRS
//
