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Database: UniProt
Entry: J0D4Q9_9BIFI
LinkDB: J0D4Q9_9BIFI
Original site: J0D4Q9_9BIFI 
ID   J0D4Q9_9BIFI            Unreviewed;       589 AA.
AC   J0D4Q9;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF9156_00800 {ECO:0000313|EMBL:EJD64925.1};
OS   Scardovia wiggsiae F0424.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Scardovia.
OX   NCBI_TaxID=857290 {ECO:0000313|EMBL:EJD64925.1, ECO:0000313|Proteomes:UP000006415};
RN   [1] {ECO:0000313|EMBL:EJD64925.1, ECO:0000313|Proteomes:UP000006415}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0424 {ECO:0000313|EMBL:EJD64925.1,
RC   ECO:0000313|Proteomes:UP000006415};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA   Baranova O.V., Blanton J.M., Tanner A.C., Mathney J., Dewhirst F.E.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA   Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Scardovia wiggsiae F0424.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJD64925.1}.
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DR   EMBL; AGZS01000003; EJD64925.1; -; Genomic_DNA.
DR   RefSeq; WP_007147864.1; NZ_JH719939.1.
DR   EnsemblBacteria; EJD64925; EJD64925; HMPREF9156_00800.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006415; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006415};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006415}.
FT   DOMAIN      273    409       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      487    556       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     281    288       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   589 AA;  64961 MW;  5C3FF5F0F062C5F9 CRC64;
     MALHHSNTEP TAQQLWSRTR NYMKDQGYLS PRDTNLVSEV SALGVFDNMI ILSVDADSLR
     STLENKLHDD INECLSTVSD KPMTFIVKVN TPNNPYTDTA NTADSDINRN NAGYKDNGGS
     GYAELGTETG INPYEPDLSI SENIGIDPGL IGNVENPEGT GTSSTFAPRK TKGYTEPYTP
     AHYGQHASEV LHNEPSAEHK DAPFHDPIYE GGREPQPADN IQNQPHLPKT QISRNAVTHL
     NPYATFDTFV QGTSNRFAKS AAVIVAEAPG TADYNPLFIY GGSGLGKTHL LNAVGNYVLR
     QDPKATVRYV TAEEFVNDFV SALAAGARKQ AALANFTKKY RNVDVLLLDD IQFFRGTETM
     EQFFHTFNEL TSTGKQIVIA SDVAPNNLKG FNERLRTRFN KGLVVDVAPP EKETRLAILR
     LKVSNSTVPV PNDVLDYIAD KITDSVRELE GALTRVTAIA TLNDQPVSRT LAEQTLHDFF
     NSDVEVTPTS IITNVAHHYT LTFDDIVGPS RTKNVAEARQ VSMYLIREMT SLSLVDIGEI
     FGGRDHSTVM HACKKIANEM GKKRALYNNV NEITMYIKQK DSISPVSRN
//
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