ID J0D8T7_HELPX Unreviewed; 856 AA.
AC J0D8T7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574};
GN Name=clpB {ECO:0000313|EMBL:EJB82258.1};
GN ORFNames=HPHPH3_0373 {ECO:0000313|EMBL:EJB82258.1};
OS Helicobacter pylori Hp H-3.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992059 {ECO:0000313|EMBL:EJB82258.1, ECO:0000313|Proteomes:UP000004029};
RN [1] {ECO:0000313|EMBL:EJB82258.1, ECO:0000313|Proteomes:UP000004029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp H-3 {ECO:0000313|EMBL:EJB82258.1,
RC ECO:0000313|Proteomes:UP000004029};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB82258.1}.
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DR EMBL; AKOX01000002; EJB82258.1; -; Genomic_DNA.
DR RefSeq; WP_001047989.1; NZ_AKOX01000002.1.
DR AlphaFoldDB; J0D8T7; -.
DR PATRIC; fig|992059.3.peg.359; -.
DR Proteomes; UP000004029; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:EJB82258.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EJB82258.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 4..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT COILED 409..489
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 856 AA; 96702 MW; 9C5A81763EF77803 CRC64;
MNLFEKMTDQ LHETLDSALA LALHHKNAEV TPLHMLFAML NNSQGILLQA LQKMPVDIEA
LKLSVQSELN KFAKVSQISK QNIQLNQALI QSLENAQGLM AKTGDSFIAT DTYLLANMNL
FESVLKPYLD TKELQKTLES LRKGRTIQDK NDDSNLESLE KFGIDLTQKA LENKLDPVIG
RDEEIIRMMQ ILIRKTKNNP ILLGEPGVGK TAVVEGLAQR IVNKEVPKTL LNKRVVALDL
SLLVAGAKYR GEFEERLKKV IEEVKKSANV ILFIDEIHTI VGAGASEGGM DAANILKPAL
ARGELHTIGA TTLKEYRKYF EKDMALQRRF QPILLNEPSI NEALQILRGL KETLETHHNI
TINDSALIAS AKLSSRYITD RFLPDKAIDL IDEGAAQLKM QMESEPAKLS SVKRSIQRLE
MEKQALEMEN KESNHKRMQE ILKELSDLKE EKIQLEAQFE NEKEVFKEIS RLKMEMEGLK
KEAERFKRNG DYQQAAEIEY SKIPEKEKKE KELQHKWETM QQNGALLQNA LTENNIAEIV
SQWTHIPVQK MLQSEKNRVL NIESELQKRV VGQEKALKAI AKAIKRNKAG LSDSNKPIGS
FLFLGPTGVG KTESAKALAQ FLFDSDKNLI RIDMSEYMEK HAISRLIGAA PGYVGYEEGG
QLTEAVRRKP YSVVLLDEVE KAHPDVFNLL LQVLDEGHLT DSKGVRVDFK NTILILTSNV
ASGALLEEDL SEADKQKAIK ESLRQFFKPE FLNRLDEIIS FNALDSHAII NIVGILFENI
QKKALERGIN ITLDEKAKEL IAEAGFDRFY GARPLKRALY EMVEDKLAEL ILEDKIKEND
SVAFVVENNE IVPKIK
//
