ID J0ILS4_HELPX Unreviewed; 1247 AA.
AC J0ILS4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=HPHPP26_1087 {ECO:0000313|EMBL:EJC52034.1};
OS Helicobacter pylori Hp P-26.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992085 {ECO:0000313|EMBL:EJC52034.1, ECO:0000313|Proteomes:UP000005343};
RN [1] {ECO:0000313|EMBL:EJC52034.1, ECO:0000313|Proteomes:UP000005343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-26 {ECO:0000313|EMBL:EJC52034.1,
RC ECO:0000313|Proteomes:UP000005343};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC52034.1}.
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DR EMBL; AKPT01000002; EJC52034.1; -; Genomic_DNA.
DR RefSeq; WP_000384828.1; NZ_AKPT01000002.1.
DR AlphaFoldDB; J0ILS4; -.
DR PATRIC; fig|992085.3.peg.1057; -.
DR Proteomes; UP000005343; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EJC52034.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EJC52034.1}.
FT DOMAIN 485..695
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 800..909
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 1022..1185
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 1247 AA; 145411 MW; A71FF71AA098D5A1 CRC64;
MDYKKLDLPN TNYPNKEQLK AFETAFNTFL ETNPQENENH HNDAFNDLLK GVFEYKVKPT
KKIDSAILNE NNKVEVIIEF KALKNPNEFV KGGDLNVKAF HESLLYYLTE RKEGNNNLKR
LILATIKELY IIDANEFEVF NKDKEIKKAF KDCHDKKGND PRTKAFYDAC QKRLNELDRS
LKYHHIPLKK ENLALIYQAL SPNFLLKIPK YSDANTLNKD FYEELLYILG LEEQNEKGKT
LIKPSRTQNS LSDTLKKQYK NLDDEEVMAL LIAWNNRILF LRLLESLLIS FNHFENPFLT
TENFKDFNSL NTLFFEVLAK KNSERSLNKE NKILEKIPYL NSSLFDQTPL ELKGYEIRFL
ENKKLELYQN SVLKKHEEYQ KQKDWTLLKY LFEFLRIYDF TTTPKDIKDN QNKSESRLIN
PSVLGLVFEK LNGYKEGSFY TPSFITSYMC KESITPIVLD KFNATYQWDC ENLKALREKI
DRNFSSNEKA KEYLNTLLTL RICDPAVGSG HFLVSALNEM VLIAYELGLI ASLYRHDLRL
ENDEIIIHTP EDKVFKYTIP HSQNDPHHQI QKELFNLKKD IIENCLFGMD INPNSCEITK
LRLWIELLKY SYYIFEEGKN TNNLETLPNI DINIKCANSL ISRFNLNDDL KKIPNIKKKI
QEYKDLVAQY KDPNPLYPLN KQDLINKIQD LKNTFSITLK DPKTKAELEK AIEKHITNYN
DFALDDKSLL TGLNYFIPSL FGTPKLSPKE EEEAFASYGR IRALRKKLDD ALSGGEYHNA
FEWRFEFPEV LDDEGNFLGF DCIIGNPPYI RQEHIKDIKP LLQKQYQDFY NSSSDIYTYF
FALALNLLKE KGFSAFITSN KYARAKYGTK LRELLLKKTT IASYMELNAL KVFESATVDT
SIIHFIKQAP LKESVFKYYE PTENDKENLK NTLSLLMKQN SLHTESFIFA NTTLLDLRDK
MQNIGTPLKD WGIQIYRGIL TGCNEAFIIP TEKRDEILKN CDDLQKDEKG MSERERTIEL
IKPILRGKDI KRYSYEWADL WVINTHNGYT SAFKSKIPPI DIEKYPAIKA HLDSHHDAIT
TRSDQGDTPY NLRNCAYLED FEKEKIVYGE IVQEPRFYLD NGECELGGFY AEATSFILTG
EHLRYLLGML HSKLITFAFK TFYAGGGLGE SGYRYKKAFI ERLPIPKITT KNQELADKII
ALVDKILQSK AKDPKANTQE LEKEIDALVY QLYNLTDEEI KIIENGQ
//