ID J0J168_HELPX Unreviewed; 448 AA.
AC J0J168;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=malate dehydrogenase (quinone) {ECO:0000256|ARBA:ARBA00013026};
DE EC=1.1.5.4 {ECO:0000256|ARBA:ARBA00013026};
DE AltName: Full=MQO {ECO:0000256|ARBA:ARBA00031550};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|ARBA:ARBA00030660};
GN ORFNames=HPNQ4228_0306 {ECO:0000313|EMBL:EJB31302.1};
OS Helicobacter pylori NQ4228.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992025 {ECO:0000313|EMBL:EJB31302.1, ECO:0000313|Proteomes:UP000004299};
RN [1] {ECO:0000313|EMBL:EJB31302.1, ECO:0000313|Proteomes:UP000004299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NQ4228 {ECO:0000313|EMBL:EJB31302.1,
RC ECO:0000313|Proteomes:UP000004299};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001139};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJB31302.1}.
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DR EMBL; AKNT01000001; EJB31302.1; -; Genomic_DNA.
DR AlphaFoldDB; J0J168; -.
DR PATRIC; fig|992025.3.peg.306; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000004299; Unassembled WGS sequence.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 448 AA; 50508 MW; 18C61A8B599B3717 CRC64;
MEFDAVIIGG GVSGCATFYT LSEYSSLKRV AIVEKCSKLA QISSSAKANS QTIHDGSIET
NYTPEKAKKV RLSAYKTRQY ALNKGLQNEV IFETQKMAIG VGDEECEFMK KRYESFKEIF
VGLEEFDKQK IKELEPNVIL GANGIDRHEN IIGHGYQKDW STMNFAKLSE NFVEEALKLK
PNNQVFLNFK VKKIEKRNDT YAVISEDIEE VYAKFVLVNA GSYALPLAQS MGYGLDLGCL
PVAGSFYFVP DLLRGKVYTV QNPKLPFAAV HGDPDAVIKS KTRIGPTALT MPKLERNKCW
LKGISLELLK MDLNRDVFKI AFDLMSDKEI RNYVFKNMVF ELPIIGKRKF LKDAQKIIPS
LSLEDLEYAH GFGEVRPQVL DRTKRKLELG EKKICTHKGI TFNMTPSPGA TSCLQNALVD
SQEIAAYLGE SFALERFYKD LSPEELEN
//
