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Database: UniProt
Entry: J0N4B0_9CLOT
LinkDB: J0N4B0_9CLOT
Original site: J0N4B0_9CLOT 
ID   J0N4B0_9CLOT            Unreviewed;       441 AA.
AC   J0N4B0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJF39262.1};
GN   ORFNames=HMPREF1141_2305 {ECO:0000313|EMBL:EJF39262.1};
OS   Clostridium sp. MSTE9.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1105031 {ECO:0000313|EMBL:EJF39262.1, ECO:0000313|Proteomes:UP000004073};
RN   [1] {ECO:0000313|EMBL:EJF39262.1, ECO:0000313|Proteomes:UP000004073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSTE9 {ECO:0000313|EMBL:EJF39262.1,
RC   ECO:0000313|Proteomes:UP000004073};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJF39262.1}.
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DR   EMBL; AKFU01000041; EJF39262.1; -; Genomic_DNA.
DR   RefSeq; WP_009064867.1; NZ_AKFU01000041.1.
DR   EnsemblBacteria; EJF39262; EJF39262; HMPREF1141_2305.
DR   PATRIC; fig|1105031.3.peg.2662; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004073; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004073};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004073}.
FT   DOMAIN      136    264       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      348    417       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     144    151       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   441 AA;  50127 MW;  37365908C67441AB CRC64;
     MIVFMESFTE AWGLVCDFCK ARITEVAYTT WIHRIRPVSL DFNKGIAVLE VPNEFHLQTL
     TRCYTSLLQE AFNEIFGEGI QIQLCTPEQL VQNKKPDAVP LSKDDYEYTF DTFIVGPSNK
     FAHAASMAVA TKPAVLYNPL FIYGNSGLGK THLLYAICNE ISKNYPQMNI IYIKGDEFTN
     ELIEAIRRGT TVEFHQRYRK ADILLVDDIQ FIAGKDSTQE EFFHTFNTLY EAKKQIVLTS
     DRPPKDIATL EERLLTRFEW GLTADVQPPD FETRIAIIKR KAELLEIDLP DNVAEYIANR
     LKNNIRQLEG AVKKMKAYYL LAGEALSIST AQAAISDIIN NHQPAPMTIE KIIEEVARTF
     GTSPEDIRSP KRSANISSAR QIAMYVVREI TQLPMTSIGE AFGGRDHSTV VYAIQQVEKN
     IGRDPKTRDT VQDIIKNIRD R
//
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