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Database: UniProt
Entry: J0NNM3_9ACTO
LinkDB: J0NNM3_9ACTO
Original site: J0NNM3_9ACTO 
ID   J0NNM3_9ACTO            Unreviewed;       541 AA.
AC   J0NNM3;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   27-SEP-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJF46367.1};
GN   ORFNames=HMPREF1318_0160 {ECO:0000313|EMBL:EJF46367.1};
OS   Actinomyces massiliensis F0489.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=1125718 {ECO:0000313|EMBL:EJF46367.1, ECO:0000313|Proteomes:UP000002941};
RN   [1] {ECO:0000313|EMBL:EJF46367.1, ECO:0000313|Proteomes:UP000002941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0489 {ECO:0000313|EMBL:EJF46367.1,
RC   ECO:0000313|Proteomes:UP000002941};
RA   Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Nelson K.E.;
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJF46367.1}.
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DR   EMBL; AKFT01000065; EJF46367.1; -; Genomic_DNA.
DR   RefSeq; WP_008730757.1; NZ_AKFT01000065.1.
DR   EnsemblBacteria; EJF46367; EJF46367; HMPREF1318_0160.
DR   PATRIC; fig|1125718.3.peg.928; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002941; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002941};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002941}.
FT   DOMAIN      231    365       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      443    512       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     239    246       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   541 AA;  59252 MW;  43571993C71E8986 CRC64;
     MPDEATTKWQ SVLEILSDST ELSTGKLSII RMTRVIDVDG TLVLVAGSPF TKSKVEEARA
     TISQALTQVW GHDVPFEVTV DTSLDTGAPA PAIPVTRTPQ PVPPQPQVPD LSSALAEADA
     PEPVVHARPS DVEPSATPSA NSPQSLHPMH STSPTHSTHP SHSTTPAYVT NPAAAFARSE
     NAQSFDKSSH LNPRYTFDNY VMGDSNRFAF AAALKVAEQP GNAASDRSTG GYNPLFIYGG
     SGLGKTHLLH AIGNHARSLY RDMIIKYVSS EEFVSDFIAS VAEGKMNDFK RRYRDVDILL
     VDDVQFLGGK EQTLEEFFHT FNTLYMANKQ VVLTSDLPPK DLKGFEKRLL SRFESGLTVD
     VQPPTLETRT AILRNKASAE GVDLPMPVLE YIASRVTTNI RELEGALIRV TAFASLTDQP
     IDQTLAEMVL KDIIANSGGG EITAAMVMTQ TADYFNLTIE DLRSKDRAQT MVHARHIAMY
     LCRELIEMST TKIGKEFGGK DHTTVMSASR KISTQMAERR DTYNQVQEIT ARIKQAAQAP
     R
//
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