ID J0QGL5_HELPX Unreviewed; 643 AA.
AC J0QGL5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574};
GN Name=clpB {ECO:0000313|EMBL:EJC10168.1};
GN ORFNames=HPHPP13_0388 {ECO:0000313|EMBL:EJC10168.1};
OS Helicobacter pylori Hp P-13.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992079 {ECO:0000313|EMBL:EJC10168.1, ECO:0000313|Proteomes:UP000005544};
RN [1] {ECO:0000313|EMBL:EJC10168.1, ECO:0000313|Proteomes:UP000005544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-13 {ECO:0000313|EMBL:EJC10168.1,
RC ECO:0000313|Proteomes:UP000005544};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC10168.1}.
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DR EMBL; AKPO01000002; EJC10168.1; -; Genomic_DNA.
DR AlphaFoldDB; J0QGL5; -.
DR PATRIC; fig|992079.3.peg.383; -.
DR Proteomes; UP000005544; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:EJC10168.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EJC10168.1}.
FT DOMAIN 4..128
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 384..530
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 551..640
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT COILED 196..276
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 643 AA; 72827 MW; 06D9D6CF55DA5C6F CRC64;
MEGLAQRIVN KEVPKTLLNK RVVALDLSLL VAGAKYRGEF EERLKKVIEE VKKSANVILF
IDEIHTIVGA GASEGGMDAA NILKPALARG ELHTIGATTL KEYRKYFEKD MALQRRFQPI
LLNEPSINEA LQILRGLKET LETHHNITIN DSALIASAKL SSRYITDRFL PDKAIDLIDE
GAAQLKMQME SEPAKLSSVK RSIQRLEMEK QALEMENKES NHKRMQEILK ELSDLKEEKI
QLEAQFENEK EVFKEISRLK MEMESLKKEA ERFKRNGDYQ QAAEIEYSKI PEKEKKEKEL
QHKWETMQQN GALLQNALTE NNIAEIVSQW THIPVQKMLQ SEKNRVLNIE SELQKRVVGQ
EKALKAIAKA IKRNKAGLSD SNKPIGSFLF LGPTGVGKTE SAKALAQFLF DSDKNLIRID
MSEYMEKHAI SRLIGAAPGY VGYEEGGQLT EAVRRKPYSV VLLDEVEKAH PDVFNLLLQV
LDEGHLTDSK GVRVDFKNTI LILTSNVASG ALLEEDLSEA DKQKAIKESL RQFFKPEFLN
RLDEIISFNA LDSHAIINIV GILFENVQKK ALERGINITL DEKAKALIAE AGFDRFYGAR
PLKRALYEMV EDKLAELILE DKIKENDSVA FVVENNEIVP KIK
//
