ID J0RL07_HELPX Unreviewed; 1472 AA.
AC J0RL07;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Eco57I restriction-modification methylase family protein {ECO:0000313|EMBL:EJC23863.1};
GN ORFNames=HPHPP4D_0911 {ECO:0000313|EMBL:EJC23863.1};
OS Helicobacter pylori Hp P-4d.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992103 {ECO:0000313|EMBL:EJC23863.1, ECO:0000313|Proteomes:UP000004286};
RN [1] {ECO:0000313|EMBL:EJC23863.1, ECO:0000313|Proteomes:UP000004286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-4d {ECO:0000313|EMBL:EJC23863.1,
RC ECO:0000313|Proteomes:UP000004286};
RA Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A.,
RA Santana-Cruz I., Tallon L.J., Ficke F.W.F.;
RT "Genome sequence of Helicobacter pylori Hp P-4d.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC23863.1}.
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DR EMBL; AKQE01000002; EJC23863.1; -; Genomic_DNA.
DR PATRIC; fig|992103.3.peg.891; -.
DR Proteomes; UP000004286; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 3.40.1350.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR039442; Mrr-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13156; Mrr_cat_2; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EJC23863.1};
KW Transferase {ECO:0000313|EMBL:EJC23863.1}.
FT DOMAIN 188..394
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 494..660
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 257..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1472 AA; 168143 MW; AED64C29EF3FE585 CRC64;
MQEISAYELI KQKLHAIPNL RHKGSLFEKI SKQFLQEHDS ANEYESIDLW NDWKLRGKER
DKGIDIVIQT TSKEYIAVQC KFHQNSISYN DISPFLTQLL SGVGEVRFKK GIIISTSNLT
SEALKAIEQI RSTGMGIDID EITEEDFIYS RIDWEKFDPT KTEDEIPLCD KKRPRPHQTE
AIEKTKKYFS DPKNARGKLI MACGTGKTYT SLKIMEALDP KITLFLAPSI ALLSQTFREY
AQEKSDPFYA SIVCSDDKTG QSKKNKSKNE DNDDIKFSEL PLKPSTRLED ILSTYERAQK
ENKRFIIFST YQSALRIKEA QEAGLGEIDL IICDEAHRTV GAMYSTNERD DKNAFTLCHS
DENIKATKRL YMTATPKVYS ESSKAKAKES DNVIYSMDDA DIFGEEIYTL NFERAIALDL
LTDYKVIILA VRSENLSGVT NSVNKKISQL EAKGTKLDKK LINNEFVCKI VGTHKGLAKQ
DVIALDDENK EDNDLKNKAD TFVSQRAISF CKSIQTSKNI KDSFETIMEC YDEELKKKSF
KNLKISIDHV DGTMNCKERL DKLENLNTFE PNICKILSNA RCLSEGVDVP ALDSVIFFDG
RSAMVDIIQA VGRVMRKAKN KKRGYIILPI ALRESEIKNL DEAVKNTNFQ NIWKVLKALR
SHDSSLVDEA TFKEKIKIFG SDDASNPDDE EELQKDKTEQ SPNDPKQAQK TLFDAILLQD
LANAVYNVMP TKLGDRNYWE NFAKKTGNIA RTLNNRLKMI FEKNPEIFDN FLTSLRGNIH
QNIKEEEALD MITSHIITKP IFDAIFGDNI KNPIAKALDK MVLKLSTLGL EGETKDLKNL
YESVKTEAAH AKSQKSQQEL IKNLYNTFFK EAFRKQSEKL GIVYTPIEVV DFILRATNGI
LKKHFNTDFN DQSITIFDPF TGTGSFIARL LSKENALISD EALKEKFQKN LFAFDIVLLS
YYIALINITQ AAQNRDSSLK NFKNIALTDS LDYLEEKTNK GALPLYEDLK ENQEIKTTLA
NKTIQVIIGN PPYSSGAKSQ NDNNQNLSHP KLEKLVYEKY GKNSTAKVGN TTRDVLIQSI
RMASDLLKDK GVLGFVVNGS FIDSKSADGF RKCVAKEFSH LYVLNLRGNA RTSGEQRKKE
GDGIFDSGSR ATIAIVFFVK DASVSDNTID YYDIGDYLKR EEKLHKLAQF ENLDSVPFKE
ITPNDKGDWI NQRNDDFEKL IPLKRDKQLK IFDTIFDLNS GGVVSGRDPW MYNFSKDALM
LSVQTCIDTY NADLKRFNEN FREAFKQRAK GVKKADLYKH LNDQEITTDK TKIAWVQNLK
TQLIKGKKLD DFSQEKIAVS LYRPFNKQYF YYERELSWSF CLMKKIFPDK SARNVVINTT
TRNFCSLISD AIPDTHFIGD ANAYPLYYYD DLGNRSYAIS GYALNLFRKH YEDNSIAEEE
IFYYIYAILH HKGYLEKYKN SLAKEAPLAL KL
//
