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Database: UniProt
Entry: J0SUB4_HELPX
LinkDB: J0SUB4_HELPX
Original site: J0SUB4_HELPX 
ID   J0SUB4_HELPX            Unreviewed;       183 AA.
AC   J0SUB4;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU366075};
GN   ORFNames=HPHPP28B_0347 {ECO:0000313|EMBL:EJC39273.1};
OS   Helicobacter pylori Hp P-28b.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=992114 {ECO:0000313|EMBL:EJC39273.1, ECO:0000313|Proteomes:UP000003138};
RN   [1] {ECO:0000313|EMBL:EJC39273.1, ECO:0000313|Proteomes:UP000003138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hp P-28b {ECO:0000313|EMBL:EJC39273.1,
RC   ECO:0000313|Proteomes:UP000003138};
RA   Blanchard T.G., Czinn S.J., McCracken C., Abolude K., Maroo A.,
RA   Santana-Cruz I., Tallon L.J., Ficke F.W.F.;
RT   "Genome sequence of Helicobacter pylori Hp P-28b.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes 6-aminopenicillinic acid and 7-
CC       aminocephalosporanic acid (ACA) derivatives.
CC       {ECO:0000256|RuleBase:RU366075}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526,
CC         ECO:0000256|RuleBase:RU366075};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU366075}.
CC   -!- SIMILARITY: Belongs to the hcp beta-lactamase family.
CC       {ECO:0000256|ARBA:ARBA00008486, ECO:0000256|RuleBase:RU366075}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJC39273.1}.
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DR   EMBL; AKQM01000003; EJC39273.1; -; Genomic_DNA.
DR   AlphaFoldDB; J0SUB4; -.
DR   PATRIC; fig|992114.3.peg.336; -.
DR   Proteomes; UP000003138; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR040239; HcpB-like.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13891:SF1; CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7; 1.
DR   PANTHER; PTHR13891; UNCHARACTERIZED; 1.
DR   Pfam; PF08238; Sel1; 5.
DR   SMART; SM00671; SEL1; 4.
DR   SUPFAM; SSF81901; HCP-like; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU366075, ECO:0000313|EMBL:EJC39273.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|RuleBase:RU366075};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
SQ   SEQUENCE   183 AA;  19754 MW;  F38487BCC4A5F6FC CRC64;
     MVIILLWSRR RKNLIKAAQY ASKACDLNNG SGCGVLGFLY GSGKGVEKNL IKAAYFYSKA
     CDLNNGGGCG NLGVLYQKGE VVEKDLTKAA YLYSKACELK DGLGCKDLGT LYYSGKGVEK
     DLIKAAYFYS KACELKESFG CGALAVLYIN GQGVEKNLTK ADQYISKACK LGDQEACEAL
     KEK
//
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