ID J0TWZ1_HELPX Unreviewed; 742 AA.
AC J0TWZ1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574};
GN Name=clpA {ECO:0000313|EMBL:EJC52863.1};
GN ORFNames=HPHPP26_0122 {ECO:0000313|EMBL:EJC52863.1};
OS Helicobacter pylori Hp P-26.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992085 {ECO:0000313|EMBL:EJC52863.1, ECO:0000313|Proteomes:UP000005343};
RN [1] {ECO:0000313|EMBL:EJC52863.1, ECO:0000313|Proteomes:UP000005343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp P-26 {ECO:0000313|EMBL:EJC52863.1,
RC ECO:0000313|Proteomes:UP000005343};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJC52863.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKPT01000001; EJC52863.1; -; Genomic_DNA.
DR RefSeq; WP_000357220.1; NZ_AKPT01000001.1.
DR AlphaFoldDB; J0TWZ1; -.
DR PATRIC; fig|992085.3.peg.113; -.
DR Proteomes; UP000005343; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF111; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPA; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:EJC52863.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:EJC52863.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..141
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
SQ SEQUENCE 742 AA; 83764 MW; B101397D35BA9FBA CRC64;
MDKFNKDLNE VLSHALDLAL DFNHVLCTTE HVLLAILEHG IGIRIFNTLE EDNYYKMEQI
LKDYLQQYIP LKNDPTKIPD RSPVLARVFK KMYASYLDSV GVEELLIFIL EYDDCYASKL
LDSFGITRSY FKSALLDFDN PNDINDNDIN NEEAPKSTPL KKYTKNLSAL AQNNALDPVI
GREEEILRVI EILGRRKKNN PLLIGEAGVG KTSIAEALAL KIAQKEVPEF LQEYEVYSLD
LALMVAGAKY RGDFEKRLKK TLKEIQQNGR IILFIDEIHT LLGAGSSNAG SLDAANMLKP
VLTDGSLKCL GATTFEEYRS VFEKDKAFNR RFSIVNVEEP SKEACYLILK NIAPLYEEHH
QVRYNESVFK ACVDLTSYYM HDKFLPDKAI ELLDEVGSRK KINPKKGKKI SVDDVQETLA
LKLKIPKMRL NSDKKALLRN LEKSLKNKIF AQTEAINLVS NAIKIQHCGL SAKNKPVGSF
LFVGPSGVGK TELAKELALN LNLHFERFDM SEYKEAHSVA KLIGSPSGYV GFEQGGLLVN
AIKKHPHCLL LLDEIEKAHP NVYDLLLQVM DNATLSDNLG NKASFKHVIL IMTSNVGSKD
KDALGFFSAK NAKYDKAVKE LLTPELRSRI DAIVPFNALS LEDFERIVSV ELDKLKALAL
EQGVILKFHK EVVKFIAQKS YQTTLGAREI KKIIHNEIKT QLSDILLLQS FKKPCKIACL
LEKNQLVLKE IKRAQKVKEN DF
//
