ID J1AQK4_9EURY Unreviewed; 1128 AA.
AC J1AQK4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=Metli_1302 {ECO:0000313|EMBL:EJG07258.1};
OS Methanofollis liminatans DSM 4140.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanofollis.
OX NCBI_TaxID=28892 {ECO:0000313|EMBL:EJG07258.1};
RN [1] {ECO:0000313|EMBL:EJG07258.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4140 {ECO:0000313|EMBL:EJG07258.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Lu M., Detter J.C.,
RA Tapia R., Han C., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schuler E., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Methanofollis liminatans DSM 4140.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CM001555; EJG07258.1; -; Genomic_DNA.
DR AlphaFoldDB; J1AQK4; -.
DR STRING; 28892.Metli_1302; -.
DR PATRIC; fig|28892.9.peg.1403; -.
DR HOGENOM; CLU_001114_1_3_2; -.
DR OrthoDB; 203178at2157; -.
DR Proteomes; UP000005095; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..442
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 450..737
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1128 AA; 124246 MW; 730D24B0517AFE4F CRC64;
MALTPRQAEA ALAHDQSICV TAGAGTGKTH VLVTKYVDLL RRGGCGVGNI LALTYTDNAA
TQMKKRIGNA LREEEGETWE KVRDDFLRAN ISTFHAFCTG CLREFPLEAG VDPGFAVLDE
REAGRIRDEA VEGLVYGEPP EAYREAVVRT LRALGPEGLK ECLLRLYAKR ETAGALFAAL
REDEGKVLDA WDARIRAGQD EAYREFREDA RCQALTRTLR DLAARYPGDA DSAMEYLRAV
GPLLPARDTA GVVAVAEVNA RFKRGFGRKE KWQAEDLALV RATFDEFKTV IESYAATCAL
ALDRADPFTR TTLAFFSDLG TVFSAFLKRC TAEKRRRHAL DFSDLIHFTH RLFTDHPALV
AEHVRGRYRY VLVDEFQDTD PVQTTILREI LGDLVEEEEH LFIVGDPKQS IYLFRDADVT
LFKRAREEIG NEVSLDVNFR STPQVVGFVN AVFSVLMAGA SRPWEFGYDP LTAHREDEGS
VELLLAPAGE DAAAARRNEA AMVARKVREV VGRLTVYPEG ERPRPAEYGD VMILLERRIN
LPACEKALSE CGIPYHVHSG LGFYARQEVY DLFNLLSYLD NGLDDVALYG VLRSPYFGIP
DADLFRMAGP LPSPLPLRDR LRRYAGEYPA SALAAASSLL ETWAALARRV PVPLLLRRVL
EDSGIYAVYG GMPDGKQCLA NVEKFVGMAR AAGNASLAAF VAEVKRAIEE EEREGEAHLD
PAATDAVGIM TVHAAKGLEF PVVVVPGLAE KPKAETAKIA IGDGLLMGVK IPDPARGFEA
CETPVFTLLK EEQARKLRAE RLRLFYVAAT RARDHLVLAG VRPEEFGTPL PDAPTRMDWL
CQAVGLSEEA VGAGGVEVGG VALRVATAIP EVEAAEERAC PPPETLPVST PAAVAVAEEE
RPLSVSEIER YLACPKEYER VYRLGQREQA LRPMEKATNW GLLLHEVLRG REPVAVCARY
GVGDPGVIAE CARVYGRFIT SPIMKGALCD RCEVPFRARV GGVTFKGAID RLVRTADGTW
VLIDYKTGRV RGDAVLAKVA EYAMQMVVYR QAAEQILGQP VRAYLYFTAL DRFVPVEVDE
GMVLSRTVRA VEWIREGCFS FPACEGCGRE GECPALSEVM GSGHNPYY
//
