ID J1ED57_9BURK Unreviewed; 742 AA.
AC J1ED57;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=(P)ppGpp synthetase, RelA/SpoT family {ECO:0000313|EMBL:EJE50199.1};
GN ORFNames=PMI14_05285 {ECO:0000313|EMBL:EJE50199.1};
OS Acidovorax sp. CF316.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax.
OX NCBI_TaxID=1144317 {ECO:0000313|EMBL:EJE50199.1, ECO:0000313|Proteomes:UP000004811};
RN [1] {ECO:0000313|EMBL:EJE50199.1, ECO:0000313|Proteomes:UP000004811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF316 {ECO:0000313|EMBL:EJE50199.1,
RC ECO:0000313|Proteomes:UP000004811};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJE50199.1}.
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DR EMBL; AKJX01000198; EJE50199.1; -; Genomic_DNA.
DR RefSeq; WP_007858348.1; NZ_AKJX01000198.1.
DR AlphaFoldDB; J1ED57; -.
DR PATRIC; fig|1144317.3.peg.4832; -.
DR Proteomes; UP000004811; Unassembled WGS sequence.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000004811}.
FT DOMAIN 409..470
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 671..742
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 742 AA; 81552 MW; F5301CEF491BD9C7 CRC64;
MKTLAPPPGP PLNTAEAVPQ LIAATAHTLP EQVNALVRAR AFAEPLIASE ALDSGENTLA
HADAVAAILK SIGGSEAMQA ASYLVYSCVH LNKPEEVITK AFGANFAALA VETTKLVRVQ
QQARGAQALD DPALQTENVR KMLLAFSRDL RVVMLRLASR LQTLRFHAAT KLPMSPSLAR
ESLQVFAQLA NRLGIWQVKW ELEDLSFRFL EPDTYKEVAR LLDEKRGERE VYMEQLRARL
ESDLRARSIS ASVQGRPKHI YSIVKKMRGK SLNFDQVYDI RALRVVVPTV KDCYAALSWV
HQRFAPIVEE FDDYIAKPKA NGYQSLHTIV RDDLNGKPIE IQIRTQAMHE HAEHGVAAHW
AYKEAGAKGY VGVSATGEYD AKIAVLRQLL AWERDLAGHA QKSNGLFEDR IYVLTPEAAV
VDLPQGATPV DFAYSVHTSL GHRCRGAKVD GVMVPLNTPL QNGQTVEIVT VKEGRPSRDW
LNAELGYLTS NRAKAKVRAW FNAQATHETV ARGREAVERL LQREGKTAVK LDDLAVQLGF
KSAEALFEVV GKDEFSLRNI ETVLRPAEPP PSSDDYLLLK KPRGNESSGP KGGVLVVGID
SLMTQLAKCC KPAPPDDIRG FVTRGKGVSV HRSDCSNFRE MAARNGERVI DVDWGLPKAS
AADKPAVYPV DVAVEAADRQ GLLRDISEVF AREKTNVIGV QTQSVKGTAW MTFTVEVADS
GRLNKVLGIV AGVQGVRSAR RR
//
