ID J1LMV2_9ACTO Unreviewed; 977 AA.
AC J1LMV2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=[glutamate--ammonia-ligase] adenylyltransferase {ECO:0000313|EMBL:EJG14485.1};
DE EC=2.7.7.42 {ECO:0000313|EMBL:EJG14485.1};
GN Name=glnE {ECO:0000313|EMBL:EJG14485.1};
GN ORFNames=HMPREF1136_2091 {ECO:0000313|EMBL:EJG14485.1};
OS Actinomyces sp. ICM47.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=936548 {ECO:0000313|EMBL:EJG14485.1, ECO:0000313|Proteomes:UP000002647};
RN [1] {ECO:0000313|EMBL:EJG14485.1, ECO:0000313|Proteomes:UP000002647}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICM47 {ECO:0000313|EMBL:EJG14485.1,
RC ECO:0000313|Proteomes:UP000002647};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJG14485.1}.
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DR EMBL; ALCA01000111; EJG14485.1; -; Genomic_DNA.
DR RefSeq; WP_009648844.1; NZ_ALCA01000111.1.
DR AlphaFoldDB; J1LMV2; -.
DR STRING; 936548.HMPREF1136_2091; -.
DR PATRIC; fig|936548.3.peg.1650; -.
DR eggNOG; COG1391; Bacteria.
DR OrthoDB; 9759366at2; -.
DR Proteomes; UP000002647; Unassembled WGS sequence.
DR GO; GO:0008882; F:[glutamate-ammonia-ligase] adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05401; NT_GlnE_GlnD_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 2.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 2.
DR InterPro; IPR023057; GlnE.
DR InterPro; IPR005190; GlnE_rpt_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR013546; PII_UdlTrfase/GS_AdlTrfase.
DR PANTHER; PTHR30621:SF0; BIFUNCTIONAL GLUTAMINE SYNTHETASE ADENYLYLTRANSFERASE_ADENYLYL-REMOVING ENZYME; 1.
DR PANTHER; PTHR30621; GLUTAMINE SYNTHETASE ADENYLYLTRANSFERASE; 1.
DR Pfam; PF08335; GlnD_UR_UTase; 2.
DR Pfam; PF03710; GlnE; 2.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 2.
DR SUPFAM; SSF81593; Nucleotidyltransferase substrate binding subunit/domain; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000313|EMBL:EJG14485.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:EJG14485.1}; Transferase {ECO:0000313|EMBL:EJG14485.1}.
FT DOMAIN 70..307
FT /note="Glutamate-ammonia ligase adenylyltransferase
FT repeated"
FT /evidence="ECO:0000259|Pfam:PF03710"
FT DOMAIN 327..469
FT /note="PII-uridylyltransferase/Glutamine-synthetase
FT adenylyltransferase"
FT /evidence="ECO:0000259|Pfam:PF08335"
FT DOMAIN 575..800
FT /note="Glutamate-ammonia ligase adenylyltransferase
FT repeated"
FT /evidence="ECO:0000259|Pfam:PF03710"
FT DOMAIN 844..970
FT /note="PII-uridylyltransferase/Glutamine-synthetase
FT adenylyltransferase"
FT /evidence="ECO:0000259|Pfam:PF08335"
SQ SEQUENCE 977 AA; 106349 MW; 2597B60BDAE60B86 CRC64;
MTPDDLRVAG FLDARRALSF LEELPAGQSW VGDLSASADP DQALLQAVRL READPGLVGA
LSRDERARRR VCAILGGSQW LGDYVIADPA RAAAINEDPG DPREVLYEAV GARTVGRGAL
VAAREATADD LRAAYRRVLL HLAADDLTSG TPEDIMPSVG ARIADLVDAT LDAGLALARR
DVDPEGSVPF AIIAMGKTGA RELNYISDVD VIYVAEAGED GDERSALEKA TRLASATASA
CSGPGTQAPL WTVDANLRPE GRNGVLVRTI ESYRQYWDKW AQTWEFQALL KARACAGDPE
LGRAFEEAAQ PYVWSASARE GFVEAARAMR RRVEDNISRS HASRELKLGR GGLRDVEFTV
QLLQLVHGRT DAFLRVRSTL EAISALREGG YIARSDADQL SSCYRFLRAL EHRTQLPRMR
RNHLIPDKDS DLRVLGRAMD PVRYPDADAI RSAIDDVRAD VRALHEDVFY RPIIAATASL
SADEASLHAE GARDRLAAIG YRDPAGALIH IAALTQGTSR RAAIQRHLLP VFISWLANGA
DPDMGLLNFR VLSEDIGESH WYLALLRDSG VAARRLMTML PNSRWIADAL AKRPEAVAWL
DDDAELAPRE PQRLTREVAA LIDRHDDATE AAARVRAVRT RELTRAAMSD LLGGVDPRGH
AIADATDAAL LGALAIAGRE EAERWGSERA HVTFVAMGRY GGRECSYASD ADVIALHEPV
GGASDSEAAA SATAIVNRVK KLLGSATSQL GIVVDLDLRP EGKNGPMSRT IASHEEYAQR
WASTWERQAA VRARPIGSSD LDERARALFE SMAYREVSES EVRDIRLLKA RMENERLPRG
SEPARHVKLG PGGLSDVEWT IQLIQMRHGR EVEGLRTPST TRAIAVARDA GLLAAPDAEI
LLSAWDLATR IRAGNTLATG RMSGVKLDVL PRDSAELSAL AAILGYGSGG LTALEEDWLR
AARQARNVME RAFWEQQ
//
