ID J1S1Q7_9ACTN Unreviewed; 393 AA.
AC J1S1Q7;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Bifunctional RNase H/acid phosphatase {ECO:0000313|EMBL:QTZ91665.1};
DE SubName: Full=Phosphoglycerate mutase {ECO:0000313|EMBL:EJJ04747.1};
GN ORFNames=SU9_009365 {ECO:0000313|EMBL:QTZ91665.1}, SU9_22125
GN {ECO:0000313|EMBL:EJJ04747.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ04747.1};
RN [1] {ECO:0000313|EMBL:EJJ04747.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ04747.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ91665.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ91665.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AJGV01000132; EJJ04747.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ91665.1; -; Genomic_DNA.
DR RefSeq; WP_006605941.1; NZ_CP072931.1.
DR AlphaFoldDB; J1S1Q7; -.
DR STRING; 1160718.SU9_22125; -.
DR KEGG; sauh:SU9_009365; -.
DR PATRIC; fig|1160718.3.peg.4476; -.
DR eggNOG; COG0328; Bacteria.
DR eggNOG; COG0406; Bacteria.
DR HOGENOM; CLU_035712_0_0_11; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009036}.
FT DOMAIN 1..140
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 133..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 197
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 273
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 249
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 393 AA; 41570 MW; 4D9EDBDCC5D3ED1A CRC64;
MARTLIVEAD GGSRGNPGPA GYGAVVLDPE TGEALAEAAE FLGTATNNVA EYKGLVAGLR
AAHALDPEAD IRVRMDSKLV VEQMSGRWKI KHPDMKPLAA EARSVFPPDR VSYEWIPRAQ
NKHADRLANE AMDAGKSGKQ WEPRDSRAAL DTAAPVRSPA ARAADASAEA ADEAAEAPSA
GWGPDLGPPA TFVLLRHGET ALTPEKRFSG SGGTDPELSA AGRRQAEATA AALAARGTIQ
AVVSSPLRRC RETAEAVAAR LGLEVRIEEG LRETDFGAWE GLTFAEVRER YPEDLDAWLA
SAKAEPTGGG ESFAAVARRV AVARDKLLAR YAGRTVLLVT HVTPVKTLVR LALGAPPEAL
FRMELSAASL SAVAYYSDGN ASVRLLNETA HLR
//
