ID J1SCG0_9ACTN Unreviewed; 277 AA.
AC J1SCG0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:QTZ94986.1};
DE SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:EJJ08617.1};
GN ORFNames=SU9_02571 {ECO:0000313|EMBL:EJJ08617.1}, SU9_028965
GN {ECO:0000313|EMBL:QTZ94986.1};
OS Streptomyces auratus AGR0001.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1160718 {ECO:0000313|EMBL:EJJ08617.1};
RN [1] {ECO:0000313|EMBL:EJJ08617.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AGR0001 {ECO:0000313|EMBL:EJJ08617.1};
RX PubMed=22965094; DOI=10.1128/JB.01155-12;
RA Han X., Li M., Ding Z., Zhao J., Ji K., Wen M., Lu T.;
RT "Genome Sequence of Streptomyces auratus Strain AGR0001, a Phoslactomycin-
RT Producing Actinomycete.";
RL J. Bacteriol. 194:5472-5473(2012).
RN [2] {ECO:0000313|EMBL:QTZ94986.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AGR0001 {ECO:0000313|EMBL:QTZ94986.1};
RA Wen M.-L., Han X.-L., Xiong J.;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AJGV01000023; EJJ08617.1; -; Genomic_DNA.
DR EMBL; CP072931; QTZ94986.1; -; Genomic_DNA.
DR RefSeq; WP_006602100.1; NZ_CP072931.1.
DR AlphaFoldDB; J1SCG0; -.
DR STRING; 1160718.SU9_02571; -.
DR KEGG; sauh:SU9_028965; -.
DR PATRIC; fig|1160718.3.peg.532; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_0_1_11; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000009036; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009036}.
FT DOMAIN 18..261
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 109
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 76
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 277 AA; 29937 MW; 01240B951852C81B CRC64;
MSKVPSLTLN NGIAMPQLGF GVWQIEDDQA FTTVGQALEA GYRSIDTAAI YGNEAGTGKA
LAASGIPREE LFVTTKLWNS DHGHDAALRA FDTSLGKLGL EYVDLYLIHW PLPSRDTYID
TYKALEKIYA DGRAKAIGVS NFQPAHLERL LGETSVVPAV NQIELHPQFP QADSRAFHAR
HNIVTEAWSP LGQGKGLLEH PTIAELAAKH GRTPAQVVLR WHLQLGNVAI PKSVTPSRIA
ENIDVFGFEL DDADLAALAG LDSGNRLGPD PATFDVG
//
