ID J3AMN4_9SPHN Unreviewed; 355 AA.
AC J3AMN4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Multidrug resistance efflux pump {ECO:0000313|EMBL:EJL34191.1};
GN ORFNames=PMI02_00763 {ECO:0000313|EMBL:EJL34191.1};
OS Novosphingobium sp. AP12.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1144305 {ECO:0000313|EMBL:EJL34191.1, ECO:0000313|Proteomes:UP000007515};
RN [1] {ECO:0000313|EMBL:EJL34191.1, ECO:0000313|Proteomes:UP000007515}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP12 {ECO:0000313|EMBL:EJL34191.1,
RC ECO:0000313|Proteomes:UP000007515};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJL34191.1}.
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DR EMBL; AKKE01000016; EJL34191.1; -; Genomic_DNA.
DR RefSeq; WP_007678814.1; NZ_AKKE01000016.1.
DR AlphaFoldDB; J3AMN4; -.
DR STRING; 1144305.PMI02_00763; -.
DR PATRIC; fig|1144305.3.peg.716; -.
DR eggNOG; COG1566; Bacteria.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000007515; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF24; MULTIDRUG RESISTANCE EFFLUX PUMP; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|ARBA:ARBA00022519};
KW Reference proteome {ECO:0000313|Proteomes:UP000007515}.
FT DOMAIN 44..287
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 288..333
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT REGION 143..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 37869 MW; 30D4E13C1FD1BE9B CRC64;
MQRKTKLILG GSVALCAAAA ISVDFLLVDY GRSQWTNDAY ISADFSVVAP KVGGLVDRVA
VEDNERVRAG QEVAHIEHSD YIVAVEDAEA ALVAAQAKVD NLTASIARHE PVIGQQEATV
RADTAALRFA RANATRYHNL SAGGAGTVEQ QQRSTSQLEQ ASANRDRDVS AVAAVKHEIP
ILEAQRREAV ASVKRAEATL RQARLNLRYT HILAPVDGIV GQRSVRVGNF VNPGTSLLAV
VPLEKAYVIA NFQETQLTHV ARGQHARIAV DAFPGQPLRG TVDSLAPASG IAFSPIPPDN
ATGNFTKVVQ RIPLKIRLDP GQPLVRQLRV GMSVDVDLDT GSPGMPQATH GGMGR
//
