ID J3FX11_9PSED Unreviewed; 66 AA.
AC J3FX11;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=2-hydroxymuconate tautomerase {ECO:0000256|ARBA:ARBA00015750, ECO:0000256|RuleBase:RU362032};
DE EC=5.3.2.6 {ECO:0000256|ARBA:ARBA00012667, ECO:0000256|RuleBase:RU362032};
DE AltName: Full=4-oxalocrotonate tautomerase {ECO:0000256|ARBA:ARBA00029674, ECO:0000256|RuleBase:RU362032};
GN ORFNames=PMI26_01190 {ECO:0000313|EMBL:EJM47230.1};
OS Pseudomonas sp. GM33.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1144329 {ECO:0000313|EMBL:EJM47230.1, ECO:0000313|Proteomes:UP000007274};
RN [1] {ECO:0000313|EMBL:EJM47230.1, ECO:0000313|Proteomes:UP000007274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GM33 {ECO:0000313|EMBL:EJM47230.1,
RC ECO:0000313|Proteomes:UP000007274};
RX PubMed=23045501; DOI=10.1128/JB.01243-12;
RA Brown S.D., Utturkar S.M., Klingeman D.M., Johnson C.M., Martin S.L.,
RA Land M.L., Lu T.Y., Schadt C.W., Doktycz M.J., Pelletier D.A.;
RT "Twenty-one genome sequences from Pseudomonas species and 19 genome
RT sequences from diverse bacteria isolated from the rhizosphere and
RT endosphere of Populus deltoides.";
RL J. Bacteriol. 194:5991-5993(2012).
CC -!- FUNCTION: Catalyzes the ketonization of 2-hydroxymuconate
CC stereoselectively to yield 2-oxo-3-hexenedioate.
CC {ECO:0000256|ARBA:ARBA00003024}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-
CC enedioate; Xref=Rhea:RHEA:33431, ChEBI:CHEBI:28080,
CC ChEBI:CHEBI:64908; EC=5.3.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001379,
CC ECO:0000256|RuleBase:RU362032};
CC -!- SUBUNIT: Homohexamer. {ECO:0000256|ARBA:ARBA00011643,
CC ECO:0000256|RuleBase:RU362032}.
CC -!- SIMILARITY: Belongs to the 4-oxalocrotonate tautomerase family.
CC {ECO:0000256|ARBA:ARBA00006723, ECO:0000256|RuleBase:RU362032}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJM47230.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKJO01000033; EJM47230.1; -; Genomic_DNA.
DR RefSeq; WP_007971593.1; NZ_AKJO01000033.1.
DR AlphaFoldDB; J3FX11; -.
DR PATRIC; fig|1144329.3.peg.1175; -.
DR Proteomes; UP000007274; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR InterPro; IPR018191; 4-OT.
DR InterPro; IPR004370; 4-OT-like_dom.
DR InterPro; IPR014347; Tautomerase/MIF_sf.
DR NCBIfam; TIGR00013; taut; 1.
DR PANTHER; PTHR35530:SF1; TAUTOMERASE BSL7456-RELATED; 1.
DR PANTHER; PTHR35530; TAUTOMERASE-RELATED; 1.
DR Pfam; PF01361; Tautomerase; 1.
DR SUPFAM; SSF55331; Tautomerase/MIF; 1.
PE 3: Inferred from homology;
KW Aromatic hydrocarbons catabolism {ECO:0000256|ARBA:ARBA00022797,
KW ECO:0000256|RuleBase:RU362032}; Isomerase {ECO:0000256|RuleBase:RU362032}.
FT DOMAIN 2..60
FT /note="4-oxalocrotonate tautomerase-like"
FT /evidence="ECO:0000259|Pfam:PF01361"
FT ACT_SITE 2
FT /note="Proton acceptor; via imino nitrogen"
FT /evidence="ECO:0000256|PIRSR:PIRSR618191-1"
SQ SEQUENCE 66 AA; 7229 MW; B408F872A49A8C1C CRC64;
MPIAMIHLAE GRSEEKKHAL LLNVTQAIAQ SLDVPVDSVR VLLQEIPETQ WAAGGKTLAE
RRRGNA
//
