ID J3JBP8_9LACO Unreviewed; 676 AA.
AC J3JBP8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Alkaline phosphatase superfamily protein {ECO:0000313|EMBL:EJN55912.1};
GN ORFNames=A11Y_117536 {ECO:0000313|EMBL:EJN55912.1};
OS Loigolactobacillus coryniformis subsp. coryniformis CECT 5711.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Loigolactobacillus.
OX NCBI_TaxID=1185325 {ECO:0000313|EMBL:EJN55912.1, ECO:0000313|Proteomes:UP000007271};
RN [1] {ECO:0000313|EMBL:EJN55912.1, ECO:0000313|Proteomes:UP000007271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT5711 {ECO:0000313|Proteomes:UP000007271};
RA Rodriguez J.M.;
RT "Complete Genome Sequence of Lactobacillus coryniformis CECT5711.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LTA synthase family.
CC {ECO:0000256|ARBA:ARBA00009983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJN55912.1}.
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DR EMBL; AKFP01000027; EJN55912.1; -; Genomic_DNA.
DR AlphaFoldDB; J3JBP8; -.
DR STRING; 1185325.A11Y_117536; -.
DR PATRIC; fig|1185325.3.peg.1291; -.
DR Proteomes; UP000007271; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.170; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007271};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 204..500
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 623..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 256
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 212
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 256
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 373
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 432
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 433
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 676 AA; 76037 MW; 804BDF6EB5C7163E CRC64;
MWLNPLATTL LVFGLALYIQ RPFWRYFGLM ILATANTALL YFNVIYYRQF TDFMTINTIL
GYSKVSEGLS GSSLALARPY DVLYWLDLII LVVLLIARLI KIDQRPVPRR FPFAITSVAV
LLFSINLTLG EANRPQLLTR TFDRNYIVKY LGLDAYTVYD AVKTAQNNQT RASANGSDLT
NVLSFINQHY AAPNPKMYGI AKGRNVIIIH LESFQQFLID YKVDGREVTP FLNSLYHDDQ
TYAFSNFFHQ VGQGKTSDAE NMLETSVYGL PQGSVFTALG SDNTFQAAPA ILQQKAGYSS
AVFHGNVGSF WNRDNVYKNM GYQNFFDASY FNTTGDRSEQ YGLKDKLLFH DSVKYLEQLQ
QPFYAKFITV TNHFPFPLDS EDTDFPLPTT DDKAVNNYFG TAHYLDQALQ EFFAYLKASG
LYDNSMIVLY GDHYGLSNSD NLSLAELLGK SSDTWNDYDN AQLQRVPLMI HIPGQHDGGI
QKQYGGEIDV LPTIEHLLGI DNKGYIQFGT DLFSPQHDQV VAFRNTNFVT PSHTVIDGTI
YNNNGDEITH PSTELQATIK RQQTKVQNEL QLSDAVNNKN LLRFYTPTGF KPVDPESYNY
KNDFASLKLA GEKLGKLSTS LYAKNGDRTT SNHYKTDAAE LSDSSSDNDS ANNSDSDSNS
NSMDYSSAMS SMTGQN
//
