ID J3K2J4_COCIM Unreviewed; 1165 AA.
AC J3K2J4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Cell division control protein Cdc25 {ECO:0000313|EMBL:EAS28314.3};
GN ORFNames=CIMG_09518 {ECO:0000313|EMBL:EAS28314.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS28314.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704915; EAS28314.3; -; Genomic_DNA.
DR RefSeq; XP_001239897.2; XM_001239896.2.
DR AlphaFoldDB; J3K2J4; -.
DR STRING; 246410.J3K2J4; -.
DR GeneID; 4558885; -.
DR KEGG; cim:CIMG_09518; -.
DR VEuPathDB; FungiDB:CIMG_09518; -.
DR InParanoid; J3K2J4; -.
DR OMA; DWPGPDS; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000313|EMBL:EAS28314.3};
KW Cell division {ECO:0000313|EMBL:EAS28314.3};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 30..89
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 743..876
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 912..1148
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..123
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 129487 MW; 6F96B0F472ADE4C7 CRC64;
MSNTGNTDNH SSAETGGMAE EGYGSPIEAP PGLYVKALYD YTSDDHTSLS FRQGDIIQVL
NQLETGWWDG VIGDVRGWFP SNYCAVVPGP DAFCDRANLA AELSIESGTE DDYEDDNDDD
LDSQGNSRDD LSILPIESMA PATQEEAAYW IPQATADGRL FYYNTLTGYS TMELPLETPT
SPHESGPRNQ TNIYVPEHTR APIDLVNRSL GGYEHDYDGS ASEAEGESLL FTSNESSSRR
RRSGLSDGVS PATSLDSVNP SPVAKLLDSR APRSAGTQLH SSTSHFGAAA TTSLCIRSAP
APVSSSVPRY FLDDATQVPP SWASLVENMR QAIEAYRQAM LAGDRSQFVS RAEDISDHLR
MLLAAGSGTT DNHSGNPSII STNKALYPHF RDMMSKFSKL VLSSHIAAAD WPVPDSSKKC
LHEAEGVLSG VYGYVNIARQ QKGEDIRRLV PGFVSGSTSG GHWQNNNLCD KDPTAFLEHD
SGRDLRATPS TALDSALLDR IDDLRKAVVA NCRYLDKQLS LKDKIVTSGG HATIGDAVCA
ACVRILEAFR PWMSHIESID LAPLGTSLQN PQLADFSLQK QRAYDGVADL VLACQAMSAP
LADEWAELRS DALDTRLNDV KVITRQLEQY MSQIGFSLTL LLEQSPLESP GNLPGGKSDV
PAPMRMRSES QVRRVPPESI GIPSSYPING EDLIEQPQRT LDKAQRFFGQ PVPREQPIRD
VEETPWFLSL DHEGEVFYDT KSEVPQVKCG TLAGLVEQLT RHDKLEPSFK DTFLLTYRSF
TTASELFEML VLRFTLQPPS GLNVTELQSW TEQKQNPIRI RVVSILKSWL ETYWMEPNDN
ANTLLLRRIH AFVTNAVTNT RTPGTTQLLS LIDQRIRGLD TTARRLVPTL SAHTPTPILP
KNMKKIKFLD IDPTEFARQL TIIESRLYAK IKPTECLNKT WQKKLGPDEP DPAVNVKALI
LHSNQLTNWV AEMILTQSDV KRRMVVIKHF VTVAEKCRQM NNYSTLTSII SALGTAPIHR
LNRTWSQVSQ KTSLTLEAMR KLMASTKNFG EYRETLHLAT PPCIPFFGVY LTDLTFIEDG
IPSLTPSDLI NFSKRYKTAE VIRDIQQYQN TPYQLQPVPE LQDYVLSNMQ AAGDVHEMYD
RSLEVEPRER EDEKIARLLS ESGFL
//
