ID J3K4V2_COCIM Unreviewed; 609 AA.
AC J3K4V2;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN ORFNames=CIMG_08119 {ECO:0000313|EMBL:EAS29373.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS29373.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG704913; EAS29373.3; -; Genomic_DNA.
DR RefSeq; XP_001240956.1; XM_001240955.2.
DR AlphaFoldDB; J3K4V2; -.
DR STRING; 246410.J3K4V2; -.
DR GeneID; 4560160; -.
DR KEGG; cim:CIMG_08119; -.
DR VEuPathDB; FungiDB:CIMG_08119; -.
DR InParanoid; J3K4V2; -.
DR OMA; EVYTRQV; -.
DR OrthoDB; 146204at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0070987; P:error-free translesion synthesis; IEA:UniProt.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 111..290
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 68477 MW; 6522330F5D04B67E CRC64;
MNASENADAP LQPRSNESDE TLKYHLLGPS LTKAGQDKVD QQKVSEIIYE ASKGSKFFNH
ERLRDQALTE KISRILAQKE KLEKQDLTAH TRRADEYIAE LELSRDLSQT VVHLDCDAFF
AAVEELDRPE LRSVPMAVGK GVLTTCNYVA RKYGCRSGMA SFVAKKLCPQ LICLPQNYAK
YTAKAKEIRA ILANYDPQFE SASIDEAYLN ITEYCLTNNM EPQEAVQKLR NEIAVETKIT
VSAGIAANAK IAKIASNWNK PNGQFYVPSD RAAIMEFMAK IPVRKVNGVG RVFERELEAV
GIKMCSDIYS LRGMLATLFG QKAFQFLMQC YLGLGRTDIA PAEERQRKSV GTERTFRDLE
GFASLQDKLK STAIELERDL RVAEFKGRTL VLKIKLHTFE IISRQVVTPK PVYLADDLYK
YALPLLTKIN KETPNLKIRL MGLRCTNLVS TKRPDINFFG VKGAGAPESL IDSMSGASNE
KVMSTEEEFE AAAREERTED LQSLEALSQD LESSHQELAE VADSPAQPTA SENRSTNDDT
WTCPICSCPQ RADDMAFNQH VDFCLSKDTI KEAVDMTLIY DETIPPPQRK RAGENFFNRE
SPRKRMFFG
//
