ID J3K598_COCIM Unreviewed; 395 AA.
AC J3K598;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA polymerase II transcription factor B subunit 3 {ECO:0000256|ARBA:ARBA00022257};
DE AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit {ECO:0000256|ARBA:ARBA00033277};
DE AltName: Full=RNA polymerase II transcription factor B p38 subunit {ECO:0000256|ARBA:ARBA00029873};
GN ORFNames=CIMG_08327 {ECO:0000313|EMBL:EAS29581.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS29581.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG704913; EAS29581.3; -; Genomic_DNA.
DR RefSeq; XP_001241164.2; XM_001241163.2.
DR AlphaFoldDB; J3K598; -.
DR STRING; 246410.J3K598; -.
DR GeneID; 4560700; -.
DR KEGG; cim:CIMG_08327; -.
DR VEuPathDB; FungiDB:CIMG_08327; -.
DR InParanoid; J3K598; -.
DR OMA; PNKRDYY; -.
DR OrthoDB; 9088at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:InterPro.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16573; RING-HC_TFB3-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR InterPro; IPR004575; MAT1/Tfb3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR NCBIfam; TIGR00570; cdk7; 1.
DR PANTHER; PTHR12683; CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1; 1.
DR PANTHER; PTHR12683:SF13; CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1; 1.
DR Pfam; PF06391; MAT1; 1.
DR Pfam; PF17121; zf-C3HC4_5; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EAS29581.3};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transferase {ECO:0000313|EMBL:EAS29581.3};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..61
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 358..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 163..190
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 395 AA; 43910 MW; 80310339400C1DBE CRC64;
MPSQLNGASR HGEDDEVCPV CKSSRYLNPD MLFLINPECY HKMCESCVDR IFSAGPAPCP
VAGCHKTLRK NRFRKQTFED IGVEREVDIR KGVMGILNRR EEEFDSKRAW DDFLEQREEI
IANLVYGTDV AKTEAQLAEY AAQNAASIRH NKTLESQESA FLLQQQTLEQ EAFRQRRQAA
RQDYDEARRA KLAGRQEIIT RLATGTHEDA EAIAREAKHG GLLKKSSARR SEEERIKRKQ
AALLAESRKA GAQALPAGDT GATPAAGPCL IKGLRKIKTP EPEKPYDPFA GGLSLTNHDY
YTLKDHYPSP YLDPIRDDVR MLAGGYDLKE YYARTLLEAF AGLGCFIEEE ILAKDPPSAP
IGPSSLSSES HSALATGKAA EEGVHRPTIS SDDVF
//
