ID J3K624_COCIM Unreviewed; 631 AA.
AC J3K624;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Flavocytochrome c {ECO:0000313|EMBL:EAS29974.3};
GN ORFNames=CIMG_08720 {ECO:0000313|EMBL:EAS29974.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS29974.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; GG704913; EAS29974.3; -; Genomic_DNA.
DR RefSeq; XP_001241557.1; XM_001241556.2.
DR AlphaFoldDB; J3K624; -.
DR STRING; 246410.J3K624; -.
DR GeneID; 4559912; -.
DR KEGG; cim:CIMG_08720; -.
DR VEuPathDB; FungiDB:CIMG_08720; -.
DR InParanoid; J3K624; -.
DR OMA; EDLWVVV; -.
DR OrthoDB; 1605658at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010960; Flavocytochrome_c.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR PANTHER; PTHR43400:SF8; HYPOTHETICAL FUMARATE REDUCTASE (EUROFUNG); 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 547..623
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 499..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 68478 MW; 92B7216D114AB88E CRC64;
MATPQRVIVV GGGLSGLSAA HTVYLNGGNV LVLDKQSFFG GNSTKATSGI NGALTRTQIE
LGIGDSVKQF YEDTLKSARD KARPDLIKVL TYKSAAAVEW LQDVFDLDLT LVSRLGGHSF
PRTHRGHDAK FPGMAITYAL MQKLEELTEK EPNRVQVLKK ARVTGINREG NKVTGVTYEY
NGESHSADGV VVLATGGYAA DFTENSLLKK WRPDTFNLSS TNGVHATGDG HKMLMAIGAN
DIDMDKVQVH PTGLVDPKDP TSKWKFLAAE ALRGEGGLLL NKDGQRFADE LGHRDYVSGE
MWKEKEKGKW PIRLILNSKA SNVLDFHTRH YSGRGLMKKM TGKELAREIG CGEAALKKTF
DDYNQIAEGK KKDPFGKKYF HNLPFSVDDT FHVAVMEPVL HFTMGGIEIN DKAQVLNKEG
KPFDGLFVCG ELAGGVHGAN RLGGSSLLGC VVYGRVAGDS ASEYLFQQVL SNPGATAQSR
LNQISLHIDP SQPGKISVEW TAPGDGKGQG QVQAQISAPK ADASATPAPA AASTPAEADI
SDFKVPEKEF TMEEVAKHNK KDDLWIVVKG VVMDVSNWLD EHPGGAQALF SHMGKDATEE
FEMLHDDEVI PKYASQIVIG RVKGQTPSLK F
//
