ID J3K7H0_COCIM Unreviewed; 574 AA.
AC J3K7H0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=AMP-binding enzyme {ECO:0000313|EMBL:EAS30643.3};
GN ORFNames=CIMG_06122 {ECO:0000313|EMBL:EAS30643.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS30643.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; EAS30643.3; -; Genomic_DNA.
DR RefSeq; XP_001242226.2; XM_001242225.2.
DR AlphaFoldDB; J3K7H0; -.
DR STRING; 246410.J3K7H0; -.
DR GeneID; 4561252; -.
DR KEGG; cim:CIMG_06122; -.
DR VEuPathDB; FungiDB:CIMG_06122; -.
DR InParanoid; J3K7H0; -.
DR OMA; SISCNQA; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF265; ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 64..418
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 470..551
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 574 AA; 63609 MW; 004042B9B565D264 CRC64;
MDFFRPDEYL PLPTKDILSW IFDDPQYDQD KPVNETLSPP FPSTCWVIST LLNYIQIYIN
PHNASESISC NQARVLVRKL IAGLRANGFK NGDCLNVHSF NDIYYPILFL AVIGAGGVFA
GTNPSYTQFE LSHHIKTARV NFLISEPEIL ENVLLAAKDN NIPSSRVWVF NTNGRPLPPG
CSSWTDLMNY GEEDWVRFND LDTCKNTTAA RLFSSGTTGL PKAAVISHYN LIAQHELVFG
VISLPYEISR IVAVPMFHAS AVPSTHTSAL KAGHVVYVMR RFDLEAFLKV SQKYKVTEAS
TVPPMAVAIV KSPLSKQPFL KSVRSGAVGA APLDKGVQAQ FRALLSERGR YTQVWGMTET
SCVATRFPWP EDDTTGSVGR PIPCLEMKLI DDSGNNISAY DTRGEICVRG PTIISGYFEN
PHANAESFDS DGFFKTGDIG YCDSKTKKWY IVDRKKELIK VRGFQVAPPE IEAVLLSHPL
IMDAAVIGVT LPGEEKVEHP RAIVVRQPVP EAQSLSEEEV KRFAAARLAK YKSLTGGVKF
VDSIPKNASG KILKRLLREQ AKEEIKQGLV VPKL
//
